Aging is a natural process, but it is possible to support the body in order to maintain vitality and prevent the onset of imbalances over time.
Understanding Aging
Aging is driven by several biological processes:
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damage to DNA and proteins
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disturbances of hormone, neurotransmitter and other mediator responses
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oxidative stress
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chronic inflammation
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decline in cellular energy
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mitochondrial dysfunction
These mechanisms gradually affect how the body functions.
The Key Role of Cellular Energy
Mitochondria, the body’s energy powerhouses, produce ATP—the energy required for all cellular activity.
With age:
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energy production decreases
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oxidative stress increases
Supporting mitochondrial function is therefore essential for maintaining vitality.
NMN and NAD+: At the Core of Longevity
NMN (nicotinamide mononucleotide) is a precursor to NAD+, a molecule essential to cellular metabolism, whose levels decline gradually with age.
NAD+ plays a role in:
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energy production
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DNA repair
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inflammation regulation
Observed Benefits
Increasing NAD+ levels (or reducing its decline) is associated with:
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improved energy levels
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enhanced physical performance
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better insulin sensitivity
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cognitive support
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improved recovery
A Holistic Vision of Longevity
Longevity is not based on a single factor.
It relies on:
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nutrition
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movement
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stress management
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quality sleep
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targeted support from natural health products
Preserving Health Over Time
The goal is not only to live longer, but to live better—maintaining vitality, clarity, and overall well-being throughout life.
About Pierre Haddad
Pierre S. Haddad holds a Ph.D. in Pharmacology from the University of Montreal. For over 40 years, he has conducted scientific research in Quebec and internationally (Austria, United States, Morocco). For more than 25 years, his work has focused on natural health products, traditional medicine, and the mechanisms of action of medicinal plants, particularly in the context of metabolic diseases such as diabetes and obesity. He has received numerous awards and distinctions from academic, research, and complementary medicine communities. He currently serves as Interim Scientific Director at Maison Jacynthe.
REFERENCES
López-Otín, C. et al. (2023). The Hallmarks of Aging: An Expanding Universe. Cell, 186(2):243-278.
Covarrubias, A.J. et al. (2021) NAD(+) metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 22(2):119-141.
Yi L. et al. (2023). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience, 45(1):29-43.
Yoshino M. et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 372(6547):1224-1229.
Liao B. et al. (2021). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 18(1):54.
Kim M. et al. (2022). Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 14(4):755.
Irie J. et al. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J. 67(2):153-160.
Morifuji M. et al. (2024). Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study. Geroscience. 46(5):4671-4688.
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