Coenzyme Q10 – Powerful Antioxidant

Coenzyme Q10 - Powerful Antioxidant

• Provides a powerful antioxidant that promotes energy production, muscle and heart strength, which helps improve the ability to cope with oxidative stress and reduce shortness of breath. ^{1,2,3,4,5,6,7}
• Helps reduce the frequency of migraines and the nausea and vomiting that accompany them when taken prophylactically/preventatively. ^8,9,10,11

His role

The coenzyme activates energy production at the cellular level, acting like a vitamin in the body. It is an essential antioxidant for energy production. It helps maintain and/or support cardiovascular health by helping to reduce blood pressure. It is also considered a good protector of the body against damage caused by free radicals. Since its production decreases with age, its intake may protect the brain from degenerative conditions. ^11,12

Many people using statins often complain of muscle problems and joint pain. A 2013 study published in JAMA Internal Medicine suggested that these effects may be directly caused by "an inhibitory effect on coenzyme Q10 synthesis, selenoprotein synthesis, and the mitochondrial respiratory chain." ¹³

Here, the results observed in this study suggest that coenzyme Q10 supplementation may decrease muscle pain associated with statin treatment. ¹⁴

And the results of another study, report that coenzyme Q10 effectively reduces mild to moderate statin-related muscle symptoms, resulting in less interference of statin-related muscle symptoms with daily activities. ¹⁵

A word from our specialist: “Coenzyme Q10: is it a relevant anti-aging supplement?”

The main indication for coenzyme Q10 is its action in our cells for energy production (mitochondria). In this context, its anti-aging aspect is interesting, as well as for chronic fatigue and heart disease. It is also documented in neurological diseases. It is a molecule that we produce naturally, precisely by the mitochondria, the energy factories of our cells. As we age and with certain diseases such as heart failure, we produce less of it, which poses problems. Cholesterol medications, statins, reduce the production of coenzyme Q10. The problem with coenzyme Q10 in Quebec, and only in Quebec, is that it is a substance that, by regulation, is under the control of the pharmacist. Everywhere else, it is a natural product or even a food. If a person has neuropathy, needle-like pain in the fingertips, strange sensations, anesthesia where there is no longer any sensation, coenzyme Q10 will be part of the cocktail of products to restart nerve conduction.

References:

1. Kalpravidh RW, Wichit A, Siritanaratkul N, Fucharoen S. Effect of coenzyme Q10 as an antioxidant in β-thalassemia/Hb E patients. BioFactors 2005;25(1-4):225-234

2. Rosenfeldt F, Marasco S, Lyon W, Wowk M, Sheeran F, Bailey M, Esmore D, Davis B, Pick A, Rabinov M, Smith J, Nagley P, Pepe S. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. Journal of Thoracic Cardiovascular Surgery 2005;129(1):25-32.

3. Crane FL. Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition 2001;20(6):591-598.

4. Chello M, Mastroroberto P, Romano R, Bevacqua E, Pantaleo D, Ascione R, Marchese AR, Spampinato N. Protection by Coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Annals of Thoracic Surgery 1994;58(5):1427-1432.

5. Baggio E, Gandini R, Plancher AC, Passeri M, Carmosino G. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Molecular Aspects of Medicine 1994;15(Supplement 1): S287-S294.

6. Langsjoen PH, Folkers K, Lyson K, Muratsu K, Lyson T, Langsjoen P. Effective and safe therapy with coenzyme Q10 for cardiomyopathy. Klinische Wochenschrift 1988;66(13):583-590.

7. Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. Journal of Human Hypertension 2007;21(4):297-306.

8. Hershey AD, Powers SW, Vockell AL, Lecates SL, Ellinor PL, Segers A, Burdine D, Manning P, Kabbouche MA. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache 2007;47(1):73-80.

9. Sandor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 2005;64(4):713-715.

10. Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD. Open label trial of coenzyme Q10 as a migraine preventative. Cephalgia 2002;22(2):137-141.

11. Janson M. Orthomolecular medicine: the therapeutic use of dietary supplements for anti-aging. Clin Interv Aging. 2006;1(3):261-5. doi: 10.2147/ciia.2006.1.3.261. PMID: 18046879; PMCID: PMC2695174.

12. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M; Parkinson Study Group. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct;59(10):1541-50. doi: 10.1001/archneur.59.10.1541. PMID: 12374491.

13. Mansi I, Frei CR, Pugh MJ, Makris U, Mortensen EM. Statins and Musculoskeletal Conditions, Arthropathies, and Injuries. JAMA Intern Med. 2013;173(14):1318–1326. doi:10.1001/jamainternmed.2013.618414.

14. Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. Am J Cardiol. 2007 May 15;99(10):1409-12. doi: 10.1016/j.amjcard.2006.12.063. Epub 2007 Apr 3. PMID: 17493470.

15. Skarlovnik A, Janić M, Lunder M, Turk M, Šabovič M. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Med Sci Monit. 2014 Nov 6;20:2183-8. doi: 10.12659/MSM.890777. PMID: 25375075; PMCID: PMC4226312.

*Maison Jacynthe disclaims all liability. All information contained in this article is not intended to replace justified allopathic treatment or to disregard the expertise of the medical profession. It is up to each individual to take charge of their own health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified health professional is strongly recommended.