Detox 2024 - Week 3 - Detox Supplement, Probiotics & Body Brush

Because supplements always work better with the established lifestyle!

Detox – Its claims: Used in herbal medicine to help support liver functions, as a liver protective agent, to help relieve digestive disorders, stimulate and facilitate digestion, increase bile excretion and stimulate the gallbladder. Source of antioxidants.

It contains the following ingredients:

Milk Thistle

• Helps support liver/liver functions ¹
• Hepatoprotective properties ^2,3

1. Yan L, Yan Y. Therapeutic potential of sulforaphane in liver diseases: a review. Front Pharmacol. 2023 Aug 29; 14:1256029. doi: 10.3389/fphar.2023.1256029. PMID: 37705537; PMCID: PMC10495681.

2. Abenavoli, L. et al. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother. Res. 2018; 32:2202-2213.

3. Mengs U, Pohl RT, Mitchell T. Legalon® SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning. Curr Pharm Biotechnol. 2012 Aug;13(10):1964-70. doi:10.2174/138920112802273353. PMID: 22352731; PMCID: PMC3414726

Boldo

• Known for its beneficial effects on the liver ¹
• Has antioxidant properties ²
  

1. Mills, S., Bone, K. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone. 2005. 4. Blumenthal, M. et al. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.

2. Speisky H, Cassels BK. Boldo and boldine: an emerging case of natural drug development. Pharmacol Res. 1994 Jan-Feb;29(1):1-12. doi: 10.1016/1043-6618(94)80093-6. PMID: 8202440.

Turmeric

• Anti-inflammatory to reduce joint pain ¹
• Facilitates digestion, helps with good bile secretion ^2,3
• Helps maintain healthy blood sugar levels ⁴
• Anticarcinogenic properties ^5,6
  

1. Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895. doi:10.1080/10408398.2015.1077195. PMID: 26528921.

2. Mills, S., Bone, K. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone. 2005.

3. Blumenthal, M. et al. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.

4. Dehzad MJ, Ghalandari H, Nouri M, Askarpour M. Effects of curcumin/turmeric supplementation on glycemic indices in adults: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Diabetes Metab Syndr. 2023 Sep 19;17(10):102855. doi: 10.1016/j.dsx.2023.102855. Epub ahead of print. PMID: 37748368.

5. Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate cancer-I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells. Prostate Cancer Prostatic Dis. 2000 Aug;3(2):84-93. doi: 10.1038/sj.pcan.4500399. PMID: 12497104.

6. Jiang AJ, Jiang G, Li LT, Zheng JN. Curcumin induces apoptosis through mitochondrial pathway and caspase activation in human melanoma cells. Mol Biol Rep. 2015 Jan;42(1):267-75. doi:10.1007/s11033-014-3769-2. Epub 2014 Sep 28. PMID: 25262359.

Dandelion

• Known for its beneficial effects on the liver ¹
• Used in herbal medicine as a hepatoprotective/liver-protecting agent
• Helps increase bile flow (choleretic) and stimulate gallbladder contraction (cholagogue)
  

1. Mills, S., Bone, K. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone. 2005. 4. Blumenthal, M. et al. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.

N-Acetyl-L-Cysteine

• Antioxidant, precursor of protein synthesis and production of glutathione ^1,2
• Neuroprotective ³
  

1. Sahasrabudhe SA, Terluk MR, Kartha RV. N-acetylcysteine ​​Pharmacology and Applications in Rare Diseases-Repurposing an Old Antioxidant. Antioxidants (Basel). 2023 Jun 21;12(7):1316. doi:10.3390/antiox12071316. PMID: 37507857; PMCID: PMC10376274.

2. Yin J, Ren W, Yang G, Duan J, Huang X, Fang R, Li C, Li T, Yin Y, Hou Y, Kim SW, Wu G. L-Cysteine ​​metabolism and its nutritional implications. Mol Nutr Food Res. 2016 Jan;60(1):134-46. doi: 10.1002/mnfr.201500031. Epub 2015 Jun 12. PMID: 25929483.

3. Alkandari AF, Madhyastha S, Rao MS. N-Acetylcysteine ​​Amide against Aβ-Induced Alzheimer's-like Pathology in Rats. Int J Mol Sci. 2023 Aug 12;24(16):12733. doi:10.3390/ijms241612733. PMID: 37628913; PMCID: PMC10454451.

Tauroursodeoxycholic acid

• Neuroprotective ¹
• Hepatoprotector ²
  

1. Vang S, Longley K, Steer CJ, Low WC. The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases. Glob Adv Health Med. 2014 May;3(3):58-69. doi: 10.7453/gahmj.2014.017. PMID: 24891994; PMCID: PMC4030606.

2. Häussinger D, Kordes C. Mechanisms of Tauroursodeoxycholate-Mediated Hepatoprotection. Dig Dis. 2017;35(3):224-231. doi:10.1159/000450915. Epub 2017 Mar 1. PMID: 28249278.

L-Glutathione

• Acts in redox homeostasis, detoxification and iron metabolism in most living organisms. ¹
• Acts against oxidative stress and inflammation. ²
  

1.Cassier-Chauvat, C.; Marceau, F.; Farci, S.; Ouchane, S.; Chauvat, F. The Glutathione System: A Journey from Cyanobacteria to Higher Eukaryotes. Antioxidants 2023, 12, 1199. https://doi.org/10.3390/antiox12061199

2.Haddad JJ, Harb HL. L-gamma-Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)? Mol Immunol. 2005 May;42(9):987-1014. doi: 10.1016/j.molimm.2004.09.029. Epub 2004 Nov 23. PMID: 15829290.

Broccoli sprouts

• Sulforaphane in broccoli has antioxidant, anti-inflammatory, antidiabetic, and anticancer effects. ^1,2
• Can significantly improve fatty liver and prevent the development of fatty liver, improve insulin sensitivity, mitigate oxidative damage and liver injury. ¹
  

1. Yan L, Yan Y. Therapeutic potential of sulforaphane in liver diseases: a review. Front Pharmacol. 2023 Aug 29; 14:1256029. doi: 10.3389/fphar.2023.1256029. PMID: 37705537; PMCID: PMC10495681.

2. Vanduchova A, Anzenbacher P, Anzenbacherova E. Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. J Med Food. 2019 Feb;22(2):121-126. doi: 10.1089/jmf. 2018.0024. Epub 2018 Oct 27. PMID: 30372361.

Indications, details from the pharmacist formulator - Detox can be used:

• For digestive indications, as needed or for a short period of 7 days.
• For liver drainage treatment, under the advice of a therapist, in this case, the duration can be up to 3 months without risk.
  

The Importance of the Liver - Its Role & Signs You May Need a Detox

The liver is one of the most important organs. The liver is an extraordinary metabolic factory. It must be taken care of, and it is a largely forgotten part of the digestive system.

The liver manages:

• Glucose
• Lipids
• Hormones
• Cholesterol
• Metabolizes drugs
• Produces not only the proteins that transport lipids in the blood, but also many other important elements.
• Produces antibodies.
  

It's important to take care of it. With our lifestyles, the tendency is for fat to accumulate in the liver, a sign that we may have a slowdown in metabolic syndrome. Note that the majority of us have some fat in our livers. Fatty livers were once observed in alcoholics, but today, with the increase in obesity and junk food, non-alcoholic fatty liver disease is becoming the most common liver disease.

Here are the signs that you may need a detox:

• Fatigue
• Feeling unwell
• Waist size increasing without changing habits
• Poor digestion
• Disturbed sleep & irritation
  

Certain foods and ingredients support liver function. Supplements can help, but first, you'll need to look at your diet and change your lifestyle. For example, for a clogged liver, dietary changes and certain medicinal plants, including milk thistle, a fascinating plant for the liver because it works very well without causing side effects.

Probiotics – Its claims: Active regenerator of intestinal flora – Improves intestinal comfort.

It contains strains of Bifidobacterium longum BB536 - 1 billion CFU, Lactobacillus acidophilus LAC 361 - 0.3 billion CFU

We focus on quality. Why 1.3 billion and not 25?

The difference is that our bacteria have a stomach-passing ability far superior to others commonly offered. This is why our probiotics don't need a horsepower dose to be effective.

Here is the study carried out on the product itself at the Hôtel Dieu in Quebec.

The capsule used is a DR plus, which allows dissolution in the intestine, but the strains used (Morinaga) are very resistant to stomach acidity and reach the intestine more quickly also when taken on an empty stomach away from meals and also with colder water which allows the bacteria to transit more quickly to the intestine, and if in addition we have a gastro-resistant capsule it is even better, we reach the intestine where the bacteria begin their work.

Probiotics for children – Also for adults – Its claims: Probiotic that contributes to a healthy natural intestinal flora.

It contains the strains of Lactobacillus acidophilus LAC 361 - Minimum of 1 billion CFU, Bifidobacterium longum BB536 - Minimum of 0.7 billion CFU, Bifidobacterium breve M-16V - Minimum of 0.5 billion CFU, Bifidobacterium infantis M-63 - Minimum of 0.5 billion CFU - With arabinogalactan

Documented effects of arabinogalactan ^1,2,3,4,

• Improves intestinal flora (prebiotic effect) by increasing the concentration of beneficial Bifidobacteria and Lactobacilli.
• Improves several functional aspects of the immune system: activates macrophage phagocytosis and stimulates the effectiveness of the immune system's natural killer (NK) cells. It therefore has an immunostimulating effect in addition to its prebiotic effect.
• Measurable reduction in the level of toxins in the intestine (fecal ammonia) therefore improvement of intestinal ecology.
• Dietary Safety: Recognized as dietary fiber by the US FDA (up to 30g per day without problems or adverse effects). Its only possible side effect is a slight bloating in 3% of high-dose users.

1.Kelly GS. Larch Arabinogalactan: Clinical Relevance of a Novel Immune-Enhancing Polysaccharide. Altern Med Rev 1999; 4(2): 96-103

2. Nantz, MP, Painter, AR, Parker, ERB, McGill, C. and Percival, SS Evaluation of Arabinogalactan's Effect on Human Immunity. Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611

3.Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr. 2001 Aug;20(4):279-85.

4.https://www.arabinogalactan.com/larex/welcome/raw_materials/immunenhancer.-ParSys-0008-DownloadFile.tmp/ImmunEnhancer.pdf

Probiotics for children, much more than a probiotic!

Here you will find the documented effects of probiotics in children and other complementary studies , such as this one ¹ :

• Reduction of the duration of diarrhea and acceleration of the elimination of rotavirus in infectious gastroenteritis ( daycare centers ).

1.Saavedra JM, Bauman NA, Oung I et al. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhea and shedding of rotavirus. Lancet 1994:344:10146-1049.

Microbiota and obesity, a link?

This is what this study on the Intestinal Microbiota and Energy Balance: Role in Obesity tells us.

The microbial community that populates the human gastrointestinal tract has been reported to be associated with the development of obesity, diabetes, and liver disease. Proposed mechanisms to explain how the gut microbiota may contribute to obesity and metabolic disease include:

• Improved extraction of energy from the diet by converting dietary fiber into saturated fatty acids
• Increased intestinal permeability to bacterial lipopolysaccharides in response to consumption of high-fat diets, resulting in elevated systemic levels of bacterial lipopolysaccharides and low-grade inflammation.

Animal studies indicate differences in the physiological effects of fermentable and non-fermentable dietary fiber, as well as differences in the long- and short-term effects of fermentable dietary fiber. The conversion of fermentable dietary fiber to saturated fatty acids provides additional energy to the host, which may promote obesity.

However, epidemiological studies indicate that high-fiber diets prevent rather than promote the development of obesity.

In this other study, it is mentioned that an altered microbial composition in obesity and obesity-related disorders is associated with increased energy extraction from indigestible dietary carbohydrates, increased intestinal permeability, increased production of proinflammatory metabolites, such as lipopolysaccharides, leading to systemic inflammation and insulin resistance. Modulation of the intestinal microbiota can be achieved either by dietary manipulation or by administration of probiotics, prebiotics, aimed at improving intestinal dysbiosis in obesity and metabolic disorders.

1. Blaut M. Gut microbiota and energy balance: role in obesity. Proc Nutr Soc. 2015 Aug;74(3):227-34. doi: 10.1017/S0029665114001700. Epub 2014 Dec 18. PMID: 25518735. https://pubmed.ncbi.nlm.nih.gov/25518735/

2. Sankararaman S, Noriega K, Velayuthan S, Sferra T, Martindale R. Gut Microbiome and Its Impact on Obesity and Obesity-Related Disorders. Curr Gastroenterol Rep. 2023 Feb;25(2):31-44. doi:10.1007/s11894-022-00859-0. Epub 2022 Dec 5. PMID: 36469257. https://pubmed.ncbi.nlm.nih.gov/36469257/

Body Brush

“ Dry skin brushing is the best of all baths. No soap can cleanse and make the skin as clean as the new skin hidden beneath the old. The skin regenerates itself every 24 hours. Dry skin brushing removes the old layer of skin. This aids in the removal of uric acid crystals, catarrh, and other acids from the body. The skin should normally eliminate up to 2 pounds of bodily waste per day. ” - Dr. Bernard Jensen

Our skin, the body's largest living organ, is multifunctional: one of its functions is to eliminate bodily waste. Dry brushing your skin every day increases pore activity. This process is highly effective and removes more harmful substances than soap and water.

Skin that breathes fully is healthy skin!

To learn more about the benefits of dry brushing , see this explanatory article here.

Here in video , to see how Jacynthe uses it.

*Maison Jacynthe disclaims all liability. All information contained in this article is not intended to replace justified allopathic treatment or to disregard the expertise of the medical profession. It is up to each individual to take charge of their own health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified health professional is strongly recommended.