The liver
His role
The liver is one of the most important organs. The liver is an extraordinary metabolic factory. It must be taken care of, and it is a largely forgotten part of the digestive system.
The liver manages:
- Glucose
- Lipids
- Hormones
- Cholesterol
- Metabolizes drugs
- Produces not only the proteins that transport lipids in the blood, but also many other important elements.
- Produces antibodies.
It's important to take care of it. With our lifestyles, the tendency is for fat to accumulate in the liver, a sign that we may have a slowdown in metabolic syndrome. Note that the majority of us have some fat in our livers. Fatty livers were once observed in alcoholics, but today, with the increase in obesity and junk food, non-alcoholic fatty liver disease is becoming the most common liver disease.
Signs you may need a detox:
- Fatigue
- Feeling unwell
- Waist size increasing without changing habits
- Poor digestion
- Disturbed sleep & irritation
Certain foods and ingredients support liver function. Supplements can help, but first, you'll need to look at your diet and change your lifestyle. For example, for a clogged liver, dietary changes and certain medicinal plants, including milk thistle, a fascinating plant for the liver because it works very well without causing side effects.
Other tools to help with detox
Detox
This product is registered to: Help support liver/liver functions - Act as a liver protective agent - To help relieve digestive disturbances and stimulate digestion - To help stimulate the secretion of bile by the liver and stimulate contraction of the gallbladder - Source of antioxidants.
Indications, details from the pharmacist formulator - Since a bottle contains 20 capsules with a dosage of 3 per day, Detox can be used:
- For digestive indications, as needed or for a short period of 7 days.
- For liver drainage treatment, under the advice of a therapist, in this case, the duration can be up to 3 months without risk.
It contains the following ingredients:
Milk Thistle
- Helps support liver/liver functions 1
- Hepatoprotective properties 2,3
1. Yan L, Yan Y. Therapeutic potential of sulforaphane in liver diseases: a review. Front Pharmacol. 2023 Aug 29; 14:1256029. doi: 10.3389/fphar.2023.1256029. PMID: 37705537; PMCID: PMC10495681.
2. Abenavoli, L. et al. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytother. Res. 2018; 32:2202-2213.
3. Mengs U, Pohl RT, Mitchell T. Legalon® SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning. Curr Pharm Biotechnol. 2012 Aug;13(10):1964-70. doi:10.2174/138920112802273353. PMID: 22352731; PMCID: PMC3414726
Boldo
- Known for its beneficial effects on the liver 1
- Has antioxidant properties 2
1. Mills, S., Bone, K. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone. 2005. 4. Blumenthal, M. et al. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
2. Speisky H, Cassels BK. Boldo and boldine: an emerging case of natural drug development. Pharmacol Res. 1994 Jan-Feb;29(1):1-12. doi: 10.1016/1043-6618(94)80093-6. PMID: 8202440.
Turmeric
- Anti-inflammatory to reduce joint pain 1
- Facilitates digestion, helps with good bile secretion 2,3
- Helps maintain healthy blood sugar levels 4
- Anticarcinogenic properties 5,6
1. Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895. doi:10.1080/10408398.2015.1077195. PMID: 26528921.
2. Mills, S., Bone, K. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone. 2005.
3. Blumenthal, M. et al. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
4. Dehzad MJ, Ghalandari H, Nouri M, Askarpour M. Effects of curcumin/turmeric supplementation on glycemic indices in adults: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Diabetes Metab Syndr. 2023 Sep 19;17(10):102855. doi: 10.1016/j.dsx.2023.102855. Epub ahead of print. PMID: 37748368.
5. Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate cancer-I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells. Prostate Cancer Prostatic Dis. 2000 Aug;3(2):84-93. doi: 10.1038/sj.pcan.4500399. PMID: 12497104.
6. Jiang AJ, Jiang G, Li LT, Zheng JN. Curcumin induces apoptosis through mitochondrial pathway and caspase activation in human melanoma cells. Mol Biol Rep. 2015 Jan;42(1):267-75. doi:10.1007/s11033-014-3769-2. Epub 2014 Sep 28. PMID: 25262359.
Dandelion
- Known for its beneficial effects on the liver 1
- Used in herbal medicine as a hepatoprotective/liver-protecting agent
- Helps increase bile flow (choleretic) and stimulate gallbladder contraction (cholagogue)
1. Mills, S., Bone, K. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill Livingstone. 2005. 4. Blumenthal, M. et al. Herbal Medicine: Expanded Commission E Monographs. Boston (MA): Integrative Medicine Communications; 2000.
N-Acetyl-L-Cysteine
- Antioxidant, precursor of protein synthesis and production of glutathione 1,2
- Neuroprotective 3
1. Sahasrabudhe SA, Terluk MR, Kartha RV. N-acetylcysteine Pharmacology and Applications in Rare Diseases-Repurposing an Old Antioxidant. Antioxidants (Basel). 2023 Jun 21;12(7):1316. doi:10.3390/antiox12071316. PMID: 37507857; PMCID: PMC10376274.
2. Yin J, Ren W, Yang G, Duan J, Huang X, Fang R, Li C, Li T, Yin Y, Hou Y, Kim SW, Wu G. L-Cysteine metabolism and its nutritional implications. Mol Nutr Food Res. 2016 Jan;60(1):134-46. doi: 10.1002/mnfr.201500031. Epub 2015 Jun 12. PMID: 25929483.
3. Alkandari AF, Madhyastha S, Rao MS. N-Acetylcysteine Amide against Aβ-Induced Alzheimer's-like Pathology in Rats. Int J Mol Sci. 2023 Aug 12;24(16):12733. doi:10.3390/ijms241612733. PMID: 37628913; PMCID: PMC10454451.
Tauroursodeoxycholic acid
- Neuroprotective 1
- Hepatoprotector 2
1. Vang S, Longley K, Steer CJ, Low WC. The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases. Glob Adv Health Med. 2014 May;3(3):58-69. doi: 10.7453/gahmj.2014.017. PMID: 24891994; PMCID: PMC4030606.
2. Häussinger D, Kordes C. Mechanisms of Tauroursodeoxycholate-Mediated Hepatoprotection. Dig Dis. 2017;35(3):224-231. doi:10.1159/000450915. Epub 2017 Mar 1. PMID: 28249278.
L-Glutathione
- Acts in redox homeostasis, detoxification and iron metabolism in most living organisms. 1
- Acts against oxidative stress and inflammation. 2
1.Cassier-Chauvat, C.; Marceau, F.; Farci, S.; Ouchane, S.; Chauvat, F. The Glutathione System: A Journey from Cyanobacteria to Higher Eukaryotes. Antioxidants 2023, 12, 1199. https://doi.org/10.3390/antiox12061199
2.Haddad JJ, Harb HL. L-gamma-Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)? Mol Immunol. 2005 May;42(9):987-1014. doi: 10.1016/j.molimm.2004.09.029. Epub 2004 Nov 23. PMID: 15829290.
Broccoli sprouts
- Sulforaphane in broccoli has antioxidant, anti-inflammatory, antidiabetic, and anticancer effects. 1,2
- Can significantly improve fatty liver and prevent the development of fatty liver, improve insulin sensitivity, mitigate oxidative damage and liver injury. 1
1. Yan L, Yan Y. Therapeutic potential of sulforaphane in liver diseases: a review. Front Pharmacol. 2023 Aug 29; 14:1256029. doi: 10.3389/fphar.2023.1256029. PMID: 37705537; PMCID: PMC10495681.
2. Vanduchova A, Anzenbacher P, Anzenbacherova E. Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. J Med Food. 2019 Feb;22(2):121-126. doi: 10.1089/jmf. 2018.0024. Epub 2018 Oct 27. PMID: 30372361.
Proteins
The Importance of Protein - We see in people who don't have enough protein in their diet a much faster decline in:
- Their vitality
- Their posture
- Their musculature.
It's important to look for nutrient density. A wide selection of plant-based proteins can help make up for this deficiency:
- Hemp
- Spirulina
- Soy
- Lupin, a very interesting legume with a very high protein content and also low in carbohydrates compared to others, really to be added to the ingredients to favor.
Apple cider vinegar
Apple cider vinegar is naturally acidic and, for people with low stomach acid.
- It can help increase stomach acid levels to aid digestion. This may help prevent gas and bloating that slow digestion can cause.
- It is also an antimicrobial substance, which means it can help kill bacteria in the stomach or intestines. Excess bacteria or bacteria in the upper intestines release gas that can lead to bloating, so apple cider vinegar may help relieve symptoms. 1
1. Yagnik D, Serafin V, Shah J A. Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression. SciRep. 2018 Jan 29;8(1):1732. doi:10.1038/s41598-017-18618-x. PMID: 29379012; PMCID: PMC5788933.
Infrared sauna
Infrared saunas help our bodies because infrared rays penetrate much deeper than simple heat. Infrared rays are heat, but with different wavelengths, some penetrating deeper than others. Therefore, at the tissue level, they create a reaction that causes our bodies to release more toxins, including heavy metals. Saunas are known to be healthy. Research is piling up. 1,2
1. Laukkanen JA, Laukkanen T, Kunutsor SK. Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence. Mayo Clin Proc. 2018 Aug;93(8): 1111-1121. doi: 10.1016/j.mayocp.2018.04.008. PMID: 30077204.
2. Crinnion WJ. Sauna as a valuable clinical tool for cardiovascular, autoimmune, toxicant-induced and other chronic health problems. Altern Med Rev. 2011 Sep;16(3):215-25. PMID: 21951023.
Green tea
Consumed around the world, tea has enormous potential for health benefits, including reducing the risk of developing certain diseases, as research has shown. Among its many benefits, it is worth mentioning:
Green tea would promote long-term weight loss thanks to its 3 combined actions:
1- Increase in basal metabolic rate.
2- Improved glucose absorption by muscles.
3- Intensification of fat burning in the liver and muscles. 1
Dr. Willem suggests green tea as an aid in treating cellulite, as it is known to eliminate excess water and fat. 2
Tea and its catechins have also been shown to have positive effects on type 2 diabetes.3
Green tea may also have many antihypertensive benefits, improving cholesterol levels, insulin resistance, and inflammation. 4
1. Thielecke F, Boschmann M. The potential role of green tea catechins in the prevention of the metabolic syndrome - a review. Phytochemistry. 2009 Jan;70(1):11-24. doi: 10.1016/j.phytochem.2008.11.011. Epub 2009 Jan 13. PMID: 19147161.
2. Jean-Pierre Willem. I Want to Be a Young Centenarian: The Essentials for Taking Care of Yourself and Staying Healthy. Éditions Dudauphin, October 10, 2013. ISBN: 9782716314930
3. Iso H, Date C, Wakai K, Fukui M, Tamakoshi A; JACC Study Group. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med. 2006 Apr 18;144(8):554-62. doi:10.7326/0003-4819-144-8-200604180-00005. PMID: 16618952.
4. Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res. 2012 Jun;32(6):421-7. doi: 10.1016/j.nutres.2012.05.007. Epub 2012 Jun 20. PMID: 22749178.
Argan oil
The composition of argan oil is the source of the many health benefits that are described in the literature, mainly on the cardiovascular system, osteoarthritis associated with pain and also has a hypolipidemic effect as well as other metabolic parameters such as antidiabetic and antihypertensive. Promising results on the benefits of argan oil on nerve cells and neurological diseases have also been shown. 1
Watch to learn all about edible argan oil and its effects on metabolic diseases: a live broadcast with Pierre Haddad, pharmacologist, scientific researcher, and teacher.
1. Lizard G, Filali-Zegzouti Y, Midaoui AE. Benefits of Argan Oil on Human Health-May 4-6, 2017, Errachidia, Morocco. Int J Mol Sci. 2017 Jun 28;18(7):1383. doi:10.3390/ijms18071383. PMID: 28657597; PMCID: PMC5535876.
Metabzen (maintenance after the treatment with Detox)
Metabzen contains American Ginseng, Milk Thistle, and Turmeric. The latter two work hard on the liver and can greatly help with fat removal. The liver is one of the main organs in the organization of metabolism. Milk Thistle is beginning to be increasingly studied to help with liver diseases, such as fatty liver accumulation. 1
Vitamin D is added to the mix because its deficiency increases the risk of metabolic diseases. In general, Nordic populations around the world have low levels of vitamin D.
Bonus: by working the digestive system, especially the liver, we can free ourselves from migraines.
The liver protection of milk thistle is well known. In Europe, it is used to save people who have mushroom poisoning. 2
Turmeric is also anti-inflammatory.
1. Gillessen A, Schmidt HH. Silymarin as supportive treatment in liver diseases: A narrative review. Adv Ther. 2020 Apr;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. Epub 2020 Feb 17. PMID: 32065376
2. Mengs U, Pohl RT, Mitchell T. Legalon® SIL: the antidote of choice in patients with acute hepatotoxicity from amatoxin poisoning. Curr Pharm Biotechnol. 2012 Aug;13(10):1964-70. doi:10.2174/138920112802273353. PMID: 22352731; PMCID: PMC3414726.
Testimonials:
Lise D .: “METABZEN MY SAVIOR
I am pleased to share with you today my immense joy at learning from my doctor who called me recently because she did not understand all these wonderful and astonishing results from my latest blood tests.
She therefore tells me that the ALT level (for the liver) has decreased by 60% and that it is now normal and that other data which have been high since 2015 including CALCIUM (due to Hyperparathyroidism) which is now also normal as well as that of LDL (bad cholesterol).
So she cancels an operation for the moment.
She asks me what miraculous thing I did to have such changes so I tell her that I have been taking METABZEN for 12 months, so she advises me to continue taking it because my results are exceptional.
What is also most wonderful is that I had severe non-alcoholic steatosis which became mild steatosis a few months later with the use of METABZEN, isn't that fantastic! I am really looking forward to the next ultrasound which will probably be next fall to see if it has reduced further.
I started taking METABZEN in July 2022 and I also made some changes in my lifestyle such as intermittent fasting 14/10, reduced carbohydrates a little, increased my portion of vegetables including the excellent MJ salad, taking a fountain of youth (which is composed of Collagen, Complete and Camu Camu) in the afternoon instead of a snack. I also take Omega 3, Probiotic, vitamin D 3, Magnesium, Zinc (in winter), Hair Cocktail or Silica, Hydrogen and Protein.
I still have some small efforts to make to lower my blood sugar level but I started taking GLUCONIG at the beginning of July which will surely help me reach this goal.
I am so happy with these excellent results and so grateful to Dr. Pierre Haddad for creating METABZEN which has made all the difference in my health!
A huge thank you also to Jacynthe and Sylvain because Maison Jacynthe has changed my life for the better!!! From a more than satisfied customer! »
Eve F .: “After consuming only 1 bottle of argan oil, my good cholesterol level increased after analyzing my blood samples…which never changed despite my efforts! Wonderful!”
France M .: “Thank you, Mr. Haddad, for these great products. My husband was starting to have prediabetes and then it was gone; even his cholesterol went down. With Metabzen and Gluconing. Thank you, Jacynthe, for introducing us to exceptional people, just like you.”
Marjolaine V .: "My partner had started taking cholesterol medication, and I told him about Metabzen, which he takes regularly, and after several blood tests, his cholesterol level is stable. So, no medication."
Louise G .: “I met Pierre Haddad in Repentigny, what a humble but competent and professional man! I made a total change in my lifestyle and managed to improve my health and lose 65 pounds. I had fatty liver disease and was prediabetic, I have never felt better than I do now. To help me, I use Metabzen and Gluconing. At 62, it is possible to be in shape and in control of your health!”
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Carole B .: “Thanks to Metabzen and a change in lifestyle (eating better and cutting out alcohol), I have eliminated fatty liver disease and the beginnings of cirrhosis! So happy and grateful.”
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Fa Den : "I took Metabzen and Gluconig. They lowered my gamma levels considerably. I just finished and my blood values prove it. There you go, Jacynthe, I had to keep you updated, I'm really delighted and my abdomen volume is also smaller. Thank you."
MJ Montreal : “A woman told us that her cholesterol level had decreased with Metabzen, she came back to buy another jar.”
MJ Bruno : “Mrs. B. shared with us her well-being after taking Metabzen: she had fatty liver problems ... with a good diet and Metabzen for 3 months, she resolved the problem... what joy!! She is so satisfied.”
Jacynthe M .: "My boyfriend started the salad, Chlorophyll, chocolate shake, and Fountain of Youth before Christmas. His doctor took him off cholesterol medication because he no longer needed it. His blood sugar is stable, and he's lost 10 lbs."
Annie F .: “Two years ago, my doctor told me, following tests, that I had a fatty liver and that I had to lose 10% of my weight without any other explanation… I have been doing Jacynthe’s DETOX for two weeks and now I am taking the METABZEN tablets and my liver no longer hurts!! It’s incredible, it’s been a long time since I felt so good…
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