MJ Tonic - Super Defense Powder

MJ Tonic - Super Defense Powder

NPN 80123571

• Source of antioxidants
• Helps maintain/support immune functions
• Elderberry is traditionally used in Herbal Medicine (as an alterative) to help eliminate accumulated waste products through the kidneys, skin, and mucous membranes, to help relieve symptoms of colds and flu (such as coughs, sore throats, and upper respiratory catarrh), to induce sweating (diaphoretic), and to help relieve fever (in cases of colds or flu).

A few words and studies concerning...

Astragalus ( Astragalus membranaceus ), adaptogenic, toning & anti-aging plant

Certain medicinal plants have been used since ancient times to combat aging, including astragalus, a tonic adaptogenic herb that is among the most important in traditional Chinese medicine.

The main components of astragalus are polysaccharides, flavonoids, and saponins. Pharmacological research indicates that the component extracted from astragalus can increase telomerase activity and has effects:

• Antioxidants
• Anti-inflammatories
• Immunoregulators
• Anticancer
• Hypolipidemic
• Antihyperglycemics
• Hepatoprotectors
• Expectorants
• Diuretics

Astragalus contains a molecule called cycloastragenol which stimulates an enzyme, telomerase, capable of interrupting and reversing the aging process of cells. ¹

A number of studies have shown that telomerase activation can maintain telomere length, delay aging, and reverse age-related tissue degeneration. ^2,3

A randomized, double-blind, placebo-controlled clinical trial involving 117 relatively healthy cytomegalovirus-positive subjects aged 53 to 87 years found that cycloastragenol can lengthen telomeres. ⁴

Another study of 7,000 people over a 5-year period found that cycloastragenol improved markers of metabolic, bone, and cardiovascular health, with no adverse effects, suggesting that cycloastragenol improves health and may reduce the risk of morbidity and mortality. ⁵

Dietary cycloastragenol supplementation in female mice has been found to improve some health indicators, including glucose tolerance, osteoporosis, and skin health, without significantly increasing the overall incidence of cancer. ⁶

Based on the studies, astragalus would show good potential for wide application in aging and aging-related diseases.

References:

1. Liu P, Zhao H, Luo Y. Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic. Aging Dis. 2017 Dec 1;8(6):868-886. doi: 10.14336/AD.2017.0816. PMID: 29344421; PMCID: PMC5758356. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758356/
2. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, et al. (2011). Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature, 469:102-106. https://pubmed.ncbi.nlm.nih.gov/21113150/
3. Ait-Ghezala G, Hassan S, Tweed M, Paris D, Crynen G, Zakirova Z, et al. (2016). Identification of telomerase-activating blends from naturally occurring compounds. Altern Ther Health Med, 22 Suppl 2:6-14. https://pubmed.ncbi.nlm.nih.gov/27433836/
4. Salvador L, Singaravelu G, Harley CB, Flom P, Suram A, Raffaele JM (2016). A natural product telomerase activator lengthens telomeres in humans: a randomized, double blind, and placebo controlled study. Rejuvenation Res, 19:478-484. https://pubmed.ncbi.nlm.nih.gov/26950204/
5. Harley CB, Liu W, Flom PL, Raffaele JM (2013). A natural product telomerase activator as part of a health maintenance program: metabolic and cardiovascular response. Rejuvenation Res, 16:386-395. https://pubmed.ncbi.nlm.nih.gov/23808324/
6. Bernardes de Jesus B, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell. 2011 Aug;10(4):604-21. doi: 10.1111/j.1474-9726.2011.00700. x. Epub 2011 Apr 14. PMID: 21426483; PMCID:

…and elderberries ( Sambucus canadensis ), both small but powerful antioxidants!

Well known for centuries for their highly valued nutritional and medicinal properties.

Elderberries demonstrate antibacterial and antiviral activities. They are supportive agents against colds and flu. ¹

For example, a clinical trial demonstrated that elderberry supplementation reduced the duration and symptoms of the common cold in air travelers, particularly through its beneficial effects of its physical, particularly respiratory, and mental properties. ^2,3

It is also granted these properties:

• Antioxidant ⁴
• Antidiabetic ⁵
• Anti-inflammatory and immunomodulatory ⁶
• Antidepressant ⁷

A real little treasure filled with well-being!

References:

1. Krawitz C, Mraheil MA, Stein M, Imirzalioglu C, Domann E, Pleschka S, Hain T. Inhibitory activity of a standardized elderberry liquid extract against clinically relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Altern Med. 2011 Feb 25; 11:16. doi:10.1186/1472-6882-11-16. PMID: 21352539; PMCID: PMC3056848.
2. Tiralongo E, Wee SS, Lea RA. Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients. 2016 Mar 24;8(4):182. doi:10.3390/nu8040182. PMID: 27023596; PMCID: PMC4848651.
3. Roschek B Jr, Fink RC, McMichael MD, Li D, Alberte RS. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009 Jul;70(10):1255-61. doi: 10.1016/j.phytochem.2009.06.003. Epub 2009 Aug 12. PMID: 19682714.
4. M. Netzel, G. Strass, M. Herbst, H. Dietrich, R. Bitsch, I. Bitsch, T. Frank, The excretion and biological antioxidant activity of elderberry antioxidants in healthy humans, Food Research International, Volume 38, Issues 8–9, 2005, Pages 905-910, ISSN 0963-9969, https://doi.org/10.1016/j.foodres.2005.03.010 .
5. Gray AM, Abdel-Wahab YH, Flatt PR. The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro. J Nutr. 2000 Jan;130(1):15-20. doi:10.1093/jn/130.1.15. PMID: 10613759.
6. Badescu M, Badulescu O, Badescu L, Ciocoiu M. Effects of Sambucus nigra and Aronia melanocarpa extracts on immune system disorders within diabetes mellitus. Pharm Biol. 2015 Apr;53(4):533-9. doi:10.3109/13880209.2014.931441. Epub 2014 Oct 20. PMID: 25327310.
7. Mahmoudi M, Ebrahimzadeh MA, Dooshan A, Arimi A, Ghasemi N, Fathiazad F. Antidepressant activities of Sambucus ebulus and Sambucus nigra. Eur Rev Med Pharmacol Sci. 2014 Nov;18(22):3350-3. PMID: 25491608.

Baker's yeast ( Saccharomyces cerevisiae ) a great tool!

Baker's yeast (Saccharomyces cerevisiae, a single-celled fungus) has long been known for its fermentation properties, used in baking, brewing, and winemaking. Most nutritional yeasts are produced from this yeast.

Today, it is also used as a unique probiotic to promote gut health, as well as for a variety of other applications. ¹

In a comparative study, several researches are cited concerning its usefulness in several fields: ²

• Aging ³
• Regulation of gene expression ⁴
• Signal transduction ⁵
• The cell cycle ⁶
• Metabolism ^7.8
• Apoptosis ⁹
• Neurodegenerative disorders. ^10,11

This yeast is undoubtedly very interesting on several levels.

References:

1. https://www.toutsurlalevure.fr/quest-ce-que-la-levure/quest-ce-que-saccharomyces-cerevisiae/
2. Karathia H, Vilaprinyo E, Sorribas A, Alves R. Saccharomyces cerevisiae as a model organism: a comparative study. PLoS One. 2011 Feb 2;6(2): e16015. doi:10.1371/journal.pone.0016015. PMID: 21311596; PMCID: PMC3032731.
3. Murakami C, Kaeberlein M. Quantifying yeast chronological life span by outgrowth of aged cells. J Vis Exp. 2009 May 6;(27):1156. doi:10.3791/1156. PMID: 19421136; PMCID: PMC2762921.
4. Biddick R, Young ET. The disorderly study of ordered recruitment. Yeast. 2009 Apr;26(4):205-20. doi:10.1002/yea.1660. PMID: 19330770.
5. Hohmann S, Krantz M, Nordlander B. Yeast osmoregulation. Methods Enzymol. 2007; 428:29-45. doi: 10.1016/S0076-6879(07)28002-4. PMID: 17875410.
6. Nasheuer HP, Smith R, Bauerschmidt C, Grosse F, Weisshart K. Initiation of eukaryotic DNA replication: regulation and mechanisms. Prog Nucleic Acid Res Mol Biol. 2002;72:41-94. doi: 10.1016/s0079-6603(02)72067-9. PMID: 12206458.
7. Brocard-Masson C, Dumas B. The fascinating world of steroids: S. cerevisiae as a model organism for the study of hydrocortisone biosynthesis. Biotechnol Genet Eng Rev. 2006; 22:213-52. doi:10.1080/02648725.2006.10648072. PMID: 18476333.
8. López-Mirabal HR, Winther JR. Redox characteristics of the eukaryotic cytosol. Biochim Biophys Acta. 2008 Apr;1783(4):629-40. doi: 10.1016/j.bbamcr.2007.10.013. Epub 2007 Nov 7. PMID: 18039473.
9. Owsianowski E, Walter D, Fahrenkrog B. Negative regulation of apoptosis in yeast. Biochim Biophys Acta. 2008 Jul;1783(7):1303-10. doi: 10.1016/j.bbamcr.2008.03.006. Epub 2008 Mar 25. PMID: 18406356.19.
10. Miller-Fleming L, Giorgini F, Outeiro TF. Yeast as a model for studying human neurodegenerative disorders. Biotechnol J. 2008 Mar;3(3):325-38. doi:10.1002/biot.200700217. Erratum in: Biotechnol J. 2008 Mar;3(3):421. PMID: 18228539.
11. Tenreiro S, Munder MC, Alberti S, Outeiro TF. Harnessing the power of yeast to unravel the molecular basis of neurodegeneration. J Neurochem. 2013 Nov;127(4):438-52. doi:10.1111/jnc.12271. Epub 2013 May 8. PMID: 23600759.

Arabinogalactan, documented effects

• Improves intestinal flora (prebiotic effect) by increasing the concentration of beneficial Bifidobacteria and Lactobacilli. ¹
• Improves several functional aspects of the immune system: Activates the phagocytosis of macrophages and stimulates the effectiveness of the natural killer cells (NK) of the immune system. It therefore has an immunostimulating effect in addition to its prebiotic effect. ²
• Measurable reduction in the level of toxins in the intestine (fecal ammonia) therefore improvement of intestinal ecology. ³
• Food safety. Recognized as dietary fiber by the US FDA (up to 30g per day without problems or adverse effects). Its only possible side effect is a slight bloating in 3% of high-dose users. ⁴

References:

1. Kelly GS. Larch Arabinogalactan: Clinical Relevance of a Novel Immune-Enhancing Polysaccharide. Altern Med Rev 1999; 4(2): 96-103
2. Nantz, MP, Painter, AR, Parker, ERB, McGill, C. and Percival, S. Evaluation of Arabinogalactan's Effect on Human Immunity. Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611
3. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr. 2001 Aug;20(4):279-85.
4. https://www.arabinogalactan.com/larex/welcome/raw_materials/immunenhancer.-ParSys-0008-DownloadFile.tmp/ImmunEnhancer.pdf

Zinc, a support for immunity

As early as the 1960s, the discovery of zinc deficiency highlighted the importance of zinc in the immune system. Over the past few decades, numerous studies have been conducted to influence the progression of various diseases by providing zinc supplementation. ¹

Here, a review aimed to summarize the respective findings and discuss the possible molecular mechanisms by which zinc could influence viral, bacterial, and parasitic infections, autoimmune diseases, and the response to vaccination. It appears that zinc supplementation has been shown to be beneficial in diseases such as diarrhea, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory tract infections, and leishmaniasis (a parasitic disease). ²

References:

1. Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017 Nov 25;9(12):1286. doi:10.3390/nu9121286. PMID: 29186856; PMCID: PMC5748737.
2. Overbeck S, Rink L, Haase H. Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases. Arch Immunol Ther Exp (Warsz). 2008 Jan-Feb;56(1):15-30. doi:10.1007/s00005-008-0003-8. Epub 2008 Feb 5. PMID: 18250973; PMCID: PMC7079749.

Maison Jacynthe disclaims all liability. All information contained on this page is not intended to replace justified allopathic treatment or to disregard the expertise of the medical profession. It is up to each individual to take charge of their own health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified health professional is obviously recommended.