MJ Tonic Menopause Formula - To help reduce the symptoms of menopause

Menopause MJ Tonic - A formula to help reduce the symptoms of menopause

• Helps maintain cognitive function and/or reduce mental fatigue (in cases of mental tension)
• Helps increase physical capacity/physical performance (in cases of physical stress)
• Helps increase energy and stress resistance (e.g., in cases of mental or physical fatigue related to stress)
• Helps relieve symptoms associated with menopause such as hot flashes, night sweats, paresthesia (tingling, burning skin sensation), insomnia, nervousness, dizziness, fatigue, rheumatic pain, and vaginal dryness
• Provides antioxidants
• Helps reduce hot flashes associated with menopause
• Salvia officinalis, helps reduce hyperhidrosis/excessive sweating/perspiration (antihydrotic).
  

Its ingredients

Angelica gigas (Giant Angelica Root), Cynanchum wilfordii (Wilford's Cynanchum Root) and Phlomis umbrosa (Sok-dan Root)

The mixture of these three plants, Angelica gigas (giant Angelica root), Cynanchum wilfordii (Wilford's Cynanchum root) and Phlomis umbrosa (Sok-dan Root), is known as: EstroG-100^®. Here are different studies that demonstrate what this mixture can bring, in actions and benefits, during pre-, peri- and post-menopause:

In a 12-week clinical trial of 64 women, including 33 with EstroG-100^® and 31 with a placebo, treatment with EstroG-100^® showed a statistically significant improvement in the group taking EstroG-100^®: on various menopausal symptoms such as hot flashes, night sweats, paresthesia, insomnia, nervousness, melancholy, dizziness, fatigue, rheumatic pain, and vaginal dryness. No adverse effects were reported with EstroG-100^®. There were no significant changes in body weight, BMI, serum E2 levels, serum FSH levels, or liver enzymes.¹

In another study, researchers examined the safety of the plant mixture to determine its estrogenic activity. It was found that this mixture had no estrogenic activity and did not stimulate estrogen response element promoters in certain cells.²

A scientific group, after evaluating additional information on this mixture, considers that the conclusion of the scientific opinion on the safety of EstroG-100^® does not need to be revised. This group reconfirms that this mixture, as a novel food, is safe for use in dietary supplements at the maximum intake level of 175 mg/day in menopausal women.³

Panax ginseng (Ginseng)

Red ginseng (Panax ginseng) has been widely used to treat various diseases in East Asian countries. Previous studies have shown antioxidant and anti-diabetic effects. One study aimed to study the effects of red ginseng on oxidative stress and insulin resistance in menopausal women.

A randomized, double-blind, placebo-controlled trial in 82 menopausal women aged 45 to 60. Participants were randomized to receive 3 g of red ginseng per day or a placebo for 12 weeks. The activity of antioxidant enzymes (and oxidative stress markers were evaluated, and the evaluation of the homeostatic model of insulin resistance index) was calculated at baseline and at the end of the trial. In total, 71 menopausal women completed the study. Serum superoxide dismutase activity increased significantly after red ginseng supplementation over a period of 12 weeks (P <0.001), and these changes were statistically significant compared to the placebo group (P = 0.004). Among other things, red ginseng supplementation showed no effect on fasting blood glucose, fasting insulin, and insulin resistance. It was concluded that red ginseng can therefore reduce oxidative stress by increasing antioxidant enzyme activity in menopausal women.⁴

Menopausal women are vulnerable to aging and oxidative stress due to the reduction of estrogens.

Previous studies have shown that Korean red ginseng has beneficial effects on aging and antioxidant capacity. Here, the effects of red ginseng on biological aging and antioxidant capacity in menopausal women were evaluated. A double-blind, placebo-controlled clinical trial was conducted with participants, who were randomly assigned red ginseng or a placebo, and the following parameters were measured: the number of mitochondrial DNA copies as an indicator of biological aging and the total antioxidant status as a marker of antioxidant capacity. Clinical symptoms of fatigue were evaluated before and after the administration of red ginseng. There were 63 participants, including 33 who received ginseng and 30 who received a placebo. The results showed that the administration of 2 g/day of red ginseng for 8 weeks increased the number of mtDNA copies, increased antioxidant activity, and reduced fatigue symptoms more than the placebo.⁵

In recent years, the various effects of red ginseng, including immune improvement, fatigue relief, memory improvement, blood circulation improvement, antioxidant, mitigation of menopausal women's symptoms, and anti-cancer effect have been reported in clinical and basic research; red ginseng occupies an important place as a functional food for health, which is what is indicated in this monograph reporting precise information about red ginseng. These cited claims have been approved by the Korean Food and Drug Administration. ⁶

For example, it is also reported that:

• Red ginseng consumption prolonged the total sleep duration and either increased sleep efficiency or prolonged stage 2 and 3 sleep.
• A study on patients with dry mouth reports that red ginseng improved dry mouth in the secondary analysis of menopausal women among the participants.
• It is also indicated that red ginseng consumption for 24 weeks increased both hair density and thickness in patients with male and female pattern hair loss.
  

A study was conducted to determine the effect of ginseng on sexual function, quality of life, and menopausal symptoms in menopausal women with sexual dysfunction. ⁷

This randomized controlled trial was conducted on 62 women who were randomly assigned to the intervention/control groups using block randomization. The intervention group received 500 mg of Panax Ginseng and the control group received a placebo twice a day for four weeks. It is reported that there were no statistically significant differences between the two groups in terms of demographic characteristics and baseline scores of sexual function, quality of life, and menopausal symptoms. However, after the intervention, the mean total score of the female sexual function index was significantly higher in the intervention group compared to the control group (placebo). The mean total score of quality of life and menopausal symptoms were significantly lower in the treatment group than in the control group (placebo). It was concluded that ginseng has significant effects on improving sexual function and quality of life and on mitigating menopausal symptoms and that it can be an appropriate alternative to conventional therapies to promote the health of menopausal women.

Salvia officinalis (Common sage)

Due to the side effects of hormone therapy, medicinal plants and complementary medicines always present a great interest for the treatment and management of symptoms and complications of menopause, such as hot flashes, one of the most common problems during menopause.

A review article was conducted by examining clinical trial studies between 1994 and 2016. Keywords, including menopause, climacteric, hot flashes, herbs, and phytoestrogens, were used to search for herbal medicines used in clinical trials for the treatment of menopausal symptoms using databases such as PubMed, Medline, Scopus, Google Scholar, SID, and Magiran. The results of the study showed that several medicinal plants, including sage (Salvia officinalis), were effective in the treatment of acute menopausal syndrome with different mechanisms.⁸

Regarding hot flashes but also, night sweats, sleep disorders, etc...

In a randomized double-blind controlled clinical trial was conducted at the Namazi Hospital Bone Density Center in Shiraz on 66 menopausal women complaining of menopausal symptoms divided into two intervention and control groups, respectively. The intervention group received 100 mg tablets of Salvia officinalis extract, at a rate of three tablets per day for 3 months, while the control group received placebo tablets. Questionnaires were filled out at the beginning and end of the study. Hot flash and night sweat checklists were filled out one week before the intervention and at weeks 2, 4, 6, 8, 10, 12 during the intervention. Finally, the data were analyzed via the paired questionnaires and a significant threshold of 5% was considered. According to this test, the mean score of vasomotor flushing, palpitations, sleep disorders, muscle and joint pain, depression, nervousness, anxiety, and sexual desire and satisfaction significantly decreased by 1.6 - 0.4 - 1.6 - 2.1 - 1.4 - 1.2 -1.6 and 0.8 units, respectively, in the intervention group compared to the placebo control group (P < 0.001). Therefore, the mean score of one of the questionnaires significantly decreased by 3.8 units in the intervention group after the intervention (9.4 ± 3.7 vs 5.6 ± 1.9 (P < 0.05). These results showed that the extract of Salvia officinalis effectively improved menopausal symptoms such as vasomotor flushing, night sweats, heart palpitations, muscle and joint pain, depression, anxiety, sleep disorders, and sexual desire.⁹

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References:

1. Chang A, Kwak BY, Yi K, Kim JS. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. 2012 Apr;26(4):510-6. doi: 10.1002/ptr.3597. Epub 2011 Sep 2. PMID: 21887807. https://pubmed.ncbi.nlm.nih.gov/21887807/

2. Kim SJ, Jin SW, Lee GH, Kim YA, Jeong HG. Evaluation of Estrogenic Activity of Extract from the Herbal Mixture Cynanchum wilfordii Hemsley, Phlomis umbrosa Turczaninow, and Angelica gigas Nakai. Toxicol Res. 2017 Jan;33(1):71-77. doi: 10.5487/TR.2017.33.1.071. Epub 2017 Jan 15. PMID: 28133516; PMCID: PMC5266372. https://pubmed.ncbi.nlm.nih.gov/28133516/

3. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D, Bresson JL, Burlingame B, Dean T, Fairweather-Tait S, Heinonen M, Hirsch-Ernst KI, Mangelsdorf I, McArdle HJ, Naska A, Neuhäuser-Berthold M, Nowicka G, Pentieva K, Sanz Y, Siani A, Sjödin A, Stern M, Tomé D, Vinceti M, Willatts P, Engel KH, Marchelli R, Pöting A, Poulsen M, Schlatter JR, Turla E, van Loveren H. Statement on the safety of EstroG-100™ as a novel food pursuant to Regulation (EC) No 258/97. EFSA J. 2017 May 8;15(5):e04778. doi: 10.2903/j.efsa.2017.4778. PMID: 32625484; PMCID: PMC7010173. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010173/#:~:text=In%20that%20scientific%20opinion%2C%20the%20Panel%20concluded%20that%20EstroG%E2%80%90100,(514%20mg%2Fday)

4. Seo SK, Hong Y, Yun BH, Chon SJ, Jung YS, Park JH, Cho S, Choi YS, Lee BS. Antioxidative effects of Korean red ginseng in postmenopausal women: a double-blind randomized controlled trial. J Ethnopharmacol. 2014 Jul 3;154(3):753-7. doi: 10.1016/j.jep.2014.04.051. Epub 2014 May 9. PMID: 24814037. https://pubmed.ncbi.nlm.nih.gov/24814037/

5. Chung, T.-H.; Kim, J.-H.; Seol, S.-Y.; Kim, Y.-J.; Lee, Y.-J. The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study. Nutrients 2021, 13, 3090. https://doi.org/10.3390/nu13093090

6. So SH, Lee JW, Kim YS, Hyun SH, Han CK. Red ginseng monograph. J Ginseng Res. 2018 Oct;42(4):549-561. doi: 10.1016/j.jgr.2018.05.002. Epub 2018 May 26. PMID: 30337816; PMCID: PMC6190493. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190493/

7. Ghorbani Z, Mirghafourvand M, Charandabi SM, Javadzadeh Y. The effect of ginseng on sexual dysfunction in menopausal women: A double-blind, randomized, controlled trial. Complement Ther Med. 2019 Aug; 45:57-64. doi: 10.1016/j.ctim.2019.05.015. Epub 2019 May 22. PMID: 31331583. https://pubmed.ncbi.nlm.nih.gov/31331583/

8. Kargozar R, Azizi H, Salari R. A review of effective herbal medicines in controlling menopausal symptoms. Electron Physician. 2017 Nov 25;9(11):5826-5833. doi: 10.19082/5826. PMID: 29403626; PMCID: PMC5783135. https://pubmed.ncbi.nlm.nih.gov/29403626/

9. Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, Sasani MR, Emamghoreishi M, Akbarzadeh M. The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women. J Family Med Prim Care. 2020 Feb 28;9(2):1086-1092. doi: 10.4103/jfmpc.jfmpc_913_19. PMID: 32318472; PMCID: PMC7114003. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114003/

Maison Jacynthe disclaims all responsibilities. The information contained on this page is not intended to substitute a justified allopathic treatment or to set aside the expertise of the medical community. It is up to each individual to take charge of their health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified health professional is obviously suggested.