MJ Tonic Menopause Formula - To help reduce the symptoms of menopause

MJ Menopause Tonic - A formula to help reduce the symptoms of menopause

• Helps maintain cognitive functions and/or reduce mental fatigue (in cases of mental tension)
• Helps increase physical abilities/physical performance (in cases of physical stress)
• Helps increase energy and resistance to stress (e.g., in cases of stress-related mental or physical fatigue)
• Helps relieve symptoms associated with menopause such as hot flashes, night sweats, paresthesia (tingling, burning sensation of the skin), insomnia, nervousness, dizziness, fatigue, rheumatic pain and vaginal dryness
• Provides antioxidants
• Helps reduce hot flashes associated with menopause
• Salvia officinalis, helps reduce hyperhidrosis/sweating/excessive sweating (antihydrotic).
  

Its ingredients

Angelica gigas (Giant Angelica Root), Cynanchum wilfordii (Wilford's Cynanchum Root) and Phlomis umbrosa (Sok-dan Root)

The mixture of these three plants, Angelica gigas (Giant Angelica root), Cynanchum wilfordii (Wilford's Cynanchum root) and Phlomis umbrosa (Sok-dan root), is known as: EstroG-100 ^® . Here are various studies that demonstrate what this mixture can bring, in actions and benefits, in pre, peri and post-menopause periods:

In a 12-week clinical trial on 64 women, 33 with EstroG-100 ^® and 31 with placebo, treatment with EstroG-100 ^® showed a statistically significant improvement in the EstroG-100 ^® group in various menopausal symptoms such as hot flashes, night sweats, paresthesia, insomnia, nervousness, melancholy, dizziness, fatigue, rheumatic pain, and vaginal dryness. No adverse effects were reported with EstroG-100 ^® . There were no significant changes in body weight, BMI, serum E2 levels, serum FSH levels, or liver enzymes. ¹

In another study, researchers examined the safety of the herbal mixture to determine its estrogenic activity. It was found that this mixture had no estrogenic activity and did not stimulate promoters containing estrogen response elements in certain cells. ²

A Scientific Panel, which after evaluating additional information on this mixture, considers that the conclusion of the scientific opinion on the safety of EstroG-100 ^® does not need to be revised. This Panel reconfirms that this mixture, as a novel food, is safe for use in food supplements at the maximum intake level of 175 mg/day in postmenopausal women. ³

Panax ginseng (Ginseng)

Red ginseng ( Panax ginseng ) has been widely used to treat various diseases in East Asian countries. Previous studies have shown antioxidant and antidiabetic effects. One study aimed to investigate the effects of red ginseng on oxidative stress and insulin resistance in postmenopausal women.

A randomized, double-blind, placebo-controlled trial in 82 postmenopausal women aged 45 to 60 years. Participants were randomized to receive 3 g of red ginseng daily or placebo for 12 weeks. Antioxidant enzyme activity (and oxidative stress markers were assessed, and the homeostatic model assessment of insulin resistance index) was calculated at baseline and end of the trial. A total of 71 postmenopausal women completed the study. Serum superoxide dismutase activity increased significantly after red ginseng supplementation over a 12-week period (P < 0.001), and these changes were statistically significant compared to the placebo group (P = 0.004). Among other things, red ginseng supplementation showed no effect on fasting blood glucose, fasting insulin, and insulin resistance. It was concluded that red ginseng can therefore reduce oxidative stress by increasing antioxidant enzyme activity in postmenopausal women. ⁴

Postmenopausal women are vulnerable to aging and oxidative stress due to reduced estrogen.

Previous studies have shown that Korean red ginseng has beneficial effects on aging and antioxidant capacity . Here, the effects of red ginseng on biological aging and antioxidant capacity in postmenopausal women were evaluated. A double-blind, placebo-controlled clinical trial was conducted with participants, who were randomly assigned to receive red ginseng or placebo, and the following parameters were measured: mitochondrial DNA copy number as an indicator of biological aging and total antioxidant status as a marker of antioxidant capacity. Clinical symptoms of fatigue were assessed before and after administration of red ginseng. There were 63 participants, of whom 33 received ginseng and 30 received placebo. The results showed that administration of 2 g/day of red ginseng for 8 weeks increased mtDNA copy number, increased antioxidant activity, and reduced fatigue symptoms more than placebo. ⁵

In recent years, the various effects of red ginseng, including immunity enhancement, fatigue relief, memory enhancement, blood circulation improvement, antioxidation, alleviation of symptoms of menopausal women, and anticancer effect have been reported in clinical and basic research; red ginseng is said to occupy an important position as a functional food for health, which is stated in this monograph reporting specific information on red ginseng. These cited claims have been approved by the Korean Food and Drug Administration. ⁶

For example, it is also reported that:

• Red ginseng consumption prolonged total sleep time and either increased sleep efficiency or prolonged stages 2 and 3 sleep.
• A study of patients with dry mouth reports that red ginseng improved dry mouth in the secondary analysis of postmenopausal women among the participants.
• It is also reported that consuming red ginseng for 24 weeks increased both hair density and thickness in patients with male and female pattern hair loss.
  

A study was conducted to determine the effect of ginseng on sexual function, quality of life, and menopausal symptoms in postmenopausal women with sexual dysfunction. ⁷

This randomized controlled trial was conducted on 62 women who were randomly assigned to the intervention/control groups using block randomization. The intervention group received 500 mg of Panax Ginseng and the control group received a placebo twice daily for four weeks. It is reported that there were no statistically significant differences between the two groups in terms of demographic characteristics and baseline scores of sexual function, quality of life, and menopausal symptoms. However, after the intervention, the mean total score of the Female Sexual Function Index was significantly higher in the intervention group compared to the control (placebo) group. The mean total score of quality of life and menopausal symptoms were significantly lower in the treatment group than in the control (placebo) group. It was concluded that ginseng has significant effects on improving sexual function and quality of life and alleviating menopausal symptoms and may be a suitable alternative to conventional therapies to promote the health of postmenopausal women.

Salvia officinalis (Officinal sage)

Due to the side effects of hormone therapy, herbal and complementary medicines continue to be of great interest in the treatment and management of menopausal symptoms and complications, such as hot flashes, one of the most common problems during menopause.

A review article was conducted by reviewing clinical trial studies between 1994 and 2016. Keywords, which include menopause, climacteric, hot flashes, herbs, and phytoestrogens, were used to search for herbal medicines used in clinical trials for the treatment of menopausal symptoms using databases such as PubMed, Medline, Scopus, Google Scholar, SID, and Magiran. The results of the study showed that several medicinal plants, including sage (Salvia officinalis ), were effective in the treatment of acute menopausal syndrome with different mechanisms . ⁸

Concerning hot flashes but also night sweats, sleep disorders etc...

In a double-blind randomized controlled clinical trial was conducted at Namazi Hospital Bone Density Center in Shiraz on 66 postmenopausal women complaining of menopausal symptoms divided into two intervention and control groups, respectively. The intervention group received 100 mg tablets of Salvia officinalis extract, three tablets per day for 3 months, while the control group received placebo tablets. Questionnaires were completed at the beginning and end of the study. Hot flash and night sweat checklists were completed one week before the intervention and at weeks 2, 4, 6, 8, 10, 12 during the intervention. Finally, the data were analyzed via the paired questionnaires and a significant threshold of 5% was considered. According to this test, the mean score of hot flashes, palpitations, sleep disturbances, muscle and joint pain, depression, nervousness, anxiety, and sexual desire and satisfaction significantly decreased by 1.6 - 0.4 - 1.6 - 2.1 - 1.4 - 1.2 -1.6 and 0.8 units, respectively, in the intervention group compared to the placebo control group (P < 0.001). Therefore, the mean score of one of the questionnaires significantly decreased by 3.8 units in the intervention group after the intervention (9.4 ± 3.7 vs 5.6 ± 1.9 (P < 0.05). These results showed that Salvia officinalis extract effectively improved menopausal symptoms such as hot flashes, night sweats, heart palpitations, muscle and joint pain, depression, anxiety, sleep disturbances, and sexual desire. ⁹

References:

1. Chang A, Kwak BY, Yi K, Kim JS. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. 2012 Apr;26(4):510-6. doi:10.1002/ptr.3597. Epub 2011 Sep 2. PMID: 21887807. https://pubmed.ncbi.nlm.nih.gov/21887807/

2. Kim SJ, Jin SW, Lee GH, Kim YA, Jeong HG. Evaluation of Estrogenic Activity of Extract from the Herbal Mixture Cynanchum wilfordii Hemsley, Phlomis umbrosa Turczaninow, and Angelica gigas Nakai. Toxicol Res. 2017 Jan;33(1):71-77. doi: 10.5487/TR.2017.33.1.071. Epub 2017 Jan 15. PMID: 28133516; PMCID: PMC5266372. https://pubmed.ncbi.nlm.nih.gov/28133516/

3. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D, Bresson JL, Burlingame B, Dean T, Fairweather-Tait S, Heinonen M, Hirsch-Ernst KI, Mangelsdorf I, McArdle HJ, Naska A, Neuhäuser-Berthold M, Nowicka G, Pentieva K, Sanz Y, Siani A, Sjödin A, Stern M, Tomé D, Vinceti M, Willatts P, Engel KH, Marchelli R, Pöting A, Poulsen M, Schlatter JR, Turla E, van Loveren H. Statement on the safety of EstroG-100™ as a novel food pursuant to Regulation (EC) No 258/97. EFSA J. 2017 May 8;15(5):e04778. doi: 10.2903/j.efsa.2017.4778. PMID: 32625484; PMCID: PMC7010173. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010173/#:~:text=In%20that%20scientific%20opinion%2C%20the%20Panel%20concluded%20that%20EstroG%E2%80%90100,(514%20mg%2Fday)

4. Seo SK, Hong Y, Yun BH, Chon SJ, Jung YS, Park JH, Cho S, Choi YS, Lee BS. Antioxidative effects of Korean red ginseng in postmenopausal women: a double-blind randomized controlled trial. J Ethnopharmacol. 2014 Jul 3;154(3):753-7. doi: 10.1016/j.jep.2014.04.051. Epub 2014 May 9. PMID: 24814037. https://pubmed.ncbi.nlm.nih.gov/24814037/

5. Chung, T.-H.; Kim, J.-H.; Seol, S.-Y.; Kim, Y.-J.; Lee, Y.-J. The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study. Nutrients 2021, 13, 3090. https://doi.org/10.3390/nu13093090

6. So SH, Lee JW, Kim YS, Hyun SH, Han CK. Red ginseng monograph. J Ginseng Res. 2018 Oct;42(4):549-561. doi: 10.1016/j.jgr.2018.05.002. Epub 2018 May 26. PMID: 30337816; PMCID: PMC6190493. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190493/

7. Ghorbani Z, Mirghafourvand M, Charandabi SM, Javadzadeh Y. The effect of ginseng on sexual dysfunction in menopausal women: A double-blind, randomized, controlled trial. Ther Med supplement. 2019 Aug; 45:57-64. doi: 10.1016/j.ctim.2019.05.015. Epub 2019 May 22. PMID: 31331583. https://pubmed.ncbi.nlm.nih.gov/31331583/

8. Kargozar R, Azizi H, Salari R. A review of effective herbal medicines in controlling menopausal symptoms. Electron Physician. 2017 Nov 25;9(11):5826-5833. doi:10.19082/5826. PMID: 29403626; PMCID: PMC5783135. https://pubmed.ncbi.nlm.nih.gov/29403626/

9. Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, Sasani MR, Emamghoreishi M, Akbarzadeh M. The effect of Salvia officinalis extract on symptoms of flushing, night sweating, sleep disorders, and score of forgetfulness in postmenopausal women. J Family Med Prim Care. 2020 Feb 28;9(2):1086-1092. doi:10.4103/jfmpc.jfmpc_913_19. PMID: 32318472; PMCID: PMC7114003. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114003/

Maison Jacynthe disclaims all liability. All information contained on this page is not intended to replace justified allopathic treatment or to disregard the expertise of the medical profession. It is up to each individual to take charge of their own health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified health professional is obviously recommended.