Gut reset or resetting your intestine, is it possible?

The medical community is increasingly aware of the importance of the gut (microbiota) to our overall health.

First of all, what is the intestinal microbiota?

The microorganisms living in the intestines are called the “gut microbiota.” There are approximately 200 different species of bacteria, viruses, and fungi in each individual’s digestive tract. ¹

Some microorganisms are harmful to our health, but a wide variety of them are incredibly beneficial and even necessary for good health. In other words, the health of our intestines is often associated with our overall health. ²

What are the signs of an unhealthy gut microbiota?

Among the many symptoms that speak volumes about the state of the intestinal microbiota, we find ¹ :

• Gastrointestinal disorders: gas, bloating, diarrhea, constipation, SIBO
• Irritability
• Cramps
• Skin problems and rashes
• Sleep problems
• Mental health disorders
• Autoimmune diseases ³
• Endocrine disorders
• Cardiovascular diseases
• Cancer

Not to mention that there are multiple aspects of modern life that can alter the intestinal microbiota:

• High stress level
• Lack of sleep ⁴
• Processed and sugary foods causing inflammation
• Taking antibiotics
• Food intolerances and allergies ^5.6
  

How to take care of your microbiota?

By changing one's lifestyle and diet, several avenues can also be considered, such as probiotics, fermented foods (prebiotics), hydration, a diet rich in fiber, sufficient sleep and stress management can help, but this may differ from one individual to another.

Being able to identify the cause and eliminate triggers can help us see a positive change in our digestive health and overall health.

Here are some commonly suggested aids to repair your gut before starting a detox (with supporting studies):

• Glutamine: Glutamine depletion leads to villous atrophy and increased intestinal permeability. Glutamine supplementation may improve intestinal barrier function in several conditions. ^7-11
• Zinc: essential in an anti-inflammatory process, as well as for repairing tissues ¹²
• Collagen: One study has shown that using a daily 20g supplement of collagen peptides (found in hydrolyzed collagen) can reduce bloating and improve mild digestive symptoms in otherwise healthy adult women, in the absence of any other dietary or lifestyle interventions. ¹³ A review has shown that dietary peptides and amino acids modulate intestinal immune functions and influence inflammatory responses, and may be useful as alternative or adjunctive treatments in inflammatory bowel disease. ¹⁴
• Probiotics & Fiber: to nourish the flora & help the growth of good bacteria. ^15,16
• Digestive enzymes to ensure digestion ¹⁷
• Vitamin D ¹⁸ & Omega-3 ¹⁹ remain basic essentials.

Once our gut is healthy, we can begin the steps of a good lifestyle.

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References:

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2. Valdes AM, Walter J, Segal E, Spector TD. Role of the gut microbiota in nutrition and health. BMJ. 2018 Jun 13;361:k2179. doi:10.1136/bmj. k2179. PMID: 29899036; PMCID: PMC6000740. https://pmc.ncbi.nlm.nih.gov/articles/PMC6000740/

3. Balakrishnan, B., & Taneja, V. (2018). Microbial modulation of the gut microbiome for treating autoimmune diseases. Expert Review of Gastroenterology & Hepatology, 12(10), 985–996. https://doi.org/10.1080/17474124.2018.1517044

4. Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev. 2020 Oct; 53:101340. doi: 10.1016/j.smrv.2020.101340. Epub 2020 May 13. PMID: 32668369. https://www.sciencedirect.com/science/article/abs/pii/S1087079220300836?via%3Dihub

5. Brandao Gois MF, Sinha T, Spreckels JE, et al Role of the gut microbiome in mediating lactose intolerance symptoms Gut 2022;71:215-217. https://doi.org/10.1136/gutjnl-2020-323911

6. Rachid, Rimaa,b; Shatila, Talal Aa,b. The role of the gut microbiota in food allergy. Current Opinion in Pediatrics 28(6):p 748-753, December 2016. | DOI: 10.1097/MOP.0000000000000427 https://journals.lww.com/co-pediatrics/abstract/2016/12000/the_role_of_the_gut_microbiota_in_food_allergy.14.aspx

7. Perna S, Alalwan TA, Alaali Z, Alnashaba T, Gasparri C, Infantino V, Hammad L, Riva A, Petrangolini G, Allegrini P, Rondanelli M. The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review. Int J Mol Sci. 2019 Oct 22;20(20):5232. doi:10.3390/ijms20205232. PMID: 31652531; PMCID: PMC6834172. https://pmc.ncbi.nlm.nih.gov/articles/PMC6834172/pdf/ijms-20-05232.pdf

8. Fujita T, Sakurai K. Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis. Br J Surg. 1995 Jun;82(6):749-51. doi:10.1002/bjs.1800820611. PMID: 7627502. https://academic.oup.com/bjs/article-abstract/82/6/749/6167361?redirectedFrom=fulltext&login=false

9. Benjamin J, Makharia G, Ahuja V, Anand Rajan KD, Kalaivani M, Gupta SD, Joshi YK. Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trial. Dig Dis Sci. 2012 Apr;57(4):1000-12. doi:10.1007/s10620-011-1947-9. Epub 2011 Oct 26. PMID: 22038507. https://link.springer.com/article/10.1007/s10620-011-1947-9

10. Aleman RS, Moncada M, Aryana KJ. Leaky Gut and the Ingredients That Help Treat It: A Review. Molecules. 2023 Jan 7;28(2):619. doi:10.3390/molecules28020619. PMID: 36677677; PMCID: PMC9862683. https://www.mdpi.com/1420-3049/28/2/619

11. Perna S, Alalwan TA, Alaali Z, Alnashaba T, Gasparri C, Infantino V, Hammad L, Riva A, Petrangolini G, Allegrini P, Rondanelli M. The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review. Int J Mol Sci. 2019 Oct 22;20(20):5232. doi:10.3390/ijms20205232. PMID: 31652531; PMCID: PMC6834172. https://www.mdpi.com/1422-0067/20/20/5232

12. Sturniolo GC, Di Leo V, Ferronato A, D'Odorico A, D'Incà R. Zinc supplementation tightens "leaky gut" in Crohn's disease. Inflamm Bowel Dis. 2001 May;7(2):94-8. doi:10.1097/00054725-200105000-00003. PMID: 11383597. https://pubmed.ncbi.nlm.nih.gov/11383597/

13. Abrahams M, O'Grady R, Prawitt J. Effect of a Daily Collagen Peptide Supplement on Digestive Symptoms in Healthy Women: 2-Phase Mixed Methods Study. JMIR Form Res.): e2 May 31;6(5): e36339. doi:10.2196/36339. PMID: 35639457; PMCID: PMC9198822. https://formative.jmir.org/2022/5/e36339/

14, Zhang H, Hu CA, Kovacs-Nolan J, Mine Y. Bioactive dietary peptides and amino acids in inflammatory bowel disease. Amino Acids. 2015 Oct;47(10):2127-41. doi:10.1007/s00726-014-1886-9. Epub 2014 Dec 14. PMID: 25501277. https://link.springer.com/article/10.1007/s00726-014-1886-9

15. Bai AP, Ouyang Q. Probiotics and inflammatory bowel diseases. Postgrad Med J. 2006 Jun;82(968):376-82. doi: 10.1136/pgmj.2005.040899. PMID: 16754706; PMCID: PMC2563748.https://pmc.ncbi.nlm.nih.gov/articles/PMC2563748/pdf/376.pdf

16. Requena T, Martínez-Cuesta MC, Peláez C. Diet and microbiota linked in health and disease. Food Function. 2018 Feb 21;9(2):688-704. doi:10.1039/c7fo01820g. PMID: 29410981. https://pubs.rsc.org/en/content/articlelanding/2018/fo/c7fo01820g

17. Graham DY, Ketwaroo GA, Money ME, Opekun AR. Enzyme therapy for functional bowel disease-like post-prandial distress. J Dig Say. 2018 Nov;19(11):650-656. doi:10.1111/1751-2980.12655. Epub 2018 Sep 21. PMID: 30101562; PMCID: PMC6910206. https://pmc.ncbi.nlm.nih.gov/articles/PMC6910206/pdf/nihms-1061639.pdf

18. Bakke D, Sun J. Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation. Inflamm Bowel Dis. 2018 May 18;24(6):1149-1154. doi:10.1093/ibd/izy092. PMID: 29718408; PMCID: PMC6148749. https://pmc.ncbi.nlm.nih.gov/articles/PMC6148749/pdf/izy092.pdf7

19. Costantini L, Molinari R, Farinon B, Merendino N. Impact of Omega-3 Fatty Acids on the Gut Microbiota. Int J Mol Sci. 2017 Dec 7;18(12):2645. doi:10.3390/ijms18122645. PMID: 29215589; PMCID: PMC5751248. https://pmc.ncbi.nlm.nih.gov/articles/PMC5751248/pdf/ijms-18-02645.pd f

Maison Jacynthe disclaims all liability. All information contained on this page is not intended to replace justified allopathic treatment or to disregard the expertise of the medical profession. It is up to each individual to take charge of their own health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified health professional is obviously recommended.