Anti-inflammatory formula

Anti-inflammatory formula

A formula to help joints

• Helps in collagen formation
• Helps relieve joint pain and swelling associated with knee osteoarthritis
• Helps relieve joint pain and inflammation.

Its ingredients - Properties supported by science

Boswellia serrata (Indian Frankincense)

The resin of Boswellia species has been used in traditional medicine for centuries to treat various chronic inflammatory diseases. The gum resin is extracted by making incisions on the trunk of the tree called Boswellia serrata, which grows in the dry mountainous regions of India, North Africa and the Middle East. The resinous part contains monoterpenes, diterpenes, triterpenes, tetracyclic triterpene acids and four major pentacyclic triterpene acids namely β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid, which are responsible for inhibiting pro-inflammatory enzymes. ¹

A controlled trial of osteoarthritis over a period of 32 weeks of treatment demonstrated the potential efficacy and safety of a product containing, among others, boswellia and turmeric, in the symptomatic treatment of osteoarthritic knees . ²

Curcuma longa (Turmeric)

Strong molecular evidence has been published regarding its ability to target several inflammatory diseases. For example, one study reports that curcumenol (a bioactive compound derived from Curcuma longa, identified for its anti-inflammatory properties) promotes cartilage repair and improves cartilage degeneration in knee osteoarthritis. ³

Curcumin, a natural polyphenol extracted from turmeric, is a powerful antioxidant and anti-inflammatory agent . Consuming curcumin also improves muscle performance and has an anti-inflammatory effect, downregulating the production of pro-inflammatory cytokines. ⁴

A review discusses the effects of commonly consumed polyphenols, including curcumin, on osteoarthritis with an emphasis on molecular anti-arthritic mechanisms. ⁵

Palmitoylethanolamide

Palmitoylethanolamide, a type of N-acylethanolamine, belongs to a family of endogenous bioactive lipids and is known to be effective against pain and inflammation. The study demonstrated that palmitoylethanolamide could be a novel treatment to alleviate pain and reduce other associated symptoms of knee osteoarthritis. ⁶

L-Lysine

L-lysine is an essential amino acid that plays a crucial role in the formation of collagen , which is essential for skin structure and wound healing. It also helps the body absorb calcium, which is important for collagen production and bone health. A 2013 study demonstrated that increasing lysine acetylation may accelerate wound healing by promoting fibroblast migration and collagen deposition. ⁷

Piper nigrum (Piperine)

A study attempted to systematically review the scientific data on the traditional uses of Piper nigrum, phytochemical composition and pharmacological properties, such as anti-inflammatory, analgesic, neuroprotective . ⁸

Piperine is the component of black pepper that helps enhance the effectiveness of turmeric. Piperine and curcumin are folk remedies that have been used for centuries to treat various ailments in India and many other parts of the world. ⁹ It is therefore interesting to note that an animal and human study conducted by the Department of Pharmacology at St. John's Medical College in India even found that administering the two together increased the bioavailability of curcumin by 2,000% . ¹⁰

References:

1. Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci. 2011 May;73(3):255-61. doi:10.4103/0250-474X.93507. PMID: 22457547; PMCID: PMC3309643. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309643/pdf/IJPhS-73-255.pdf
2. Chopra A, Lavin P, Patwardhan B, Chitre D. A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug, on osteoarthritis of the knees. J Clin Rheumatol. 2004 Oct;10(5):236-45. doi: 10.1097/01.rhu.0000138087.47382.6d. PMID: 17043520. https://journals.lww.com/jclinrheum/abstract/2004/10000/a_32_week_randomized,_placebo_controlled_clinical.3.aspx
3. Chen W, Xiao J, Zhou Y, Liu W, Jian J, Yang J, Chen B, Ye Z, Liu J, Xu Phytomedicine. 2024 Oct;133:155922. doi: 10.1016/j.phymed.2024.155922. Epub 2024 Aug 3. PMID: 39126921. https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(24)00580-4
4. Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. Eur J Nutr. 2022 Dec;61(8):3835-3855. doi:10.1007/s00394-022-02943-7. Epub 2022 Jul 13. PMID: 35831667; PMCID: PMC9596560. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596560/pdf/394_2022_Article_2943.pdf
5. Chwan-Li Shen, Brenda J. Smith, Di-Fan Lo, Ming-Chien Chyu, Dale M. Dunn, Chung-Hwan Chen, In-Sook Kwun, Dietary polyphenols and mechanisms of osteoarthritis, The Journal of Nutritional Biochemistry, Volume 23, Issue 11, 2012, Pages 1367-1377, ISSN 0955-2863, https://doi.org/10.1016/j.jnutbio.2012.04.001.
6. Steels E, Venkatesh R, Steels E, Vitetta G, Vitetta L. A double-blind randomized placebo-controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Inflammopharmacology. 2019 Jun;27(3):475-485. doi:10.1007/s10787-019-00582-9. Epub 2019 Mar 29. PMID: 30927159. https://pubmed.ncbi.nlm.nih.gov/30927159/
7. Spallotta F, Cencioni C, Straino S, Sbardella G, Castellano S, Capogrossi MC, Martelli F, Gaetano C. Enhancement of lysine acetylation accelerates wound repair. Common Integr Biol. 2013 Sep 1;6(5):e25466. doi: 10.4161/cib.25466. Epub 2013 Jul 2. PMID: 24265859; PMCID: PMC3829946. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829946/pdf/cib-6-e25466.pdf
8. Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G, Mahomoodally MF. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications. Crit Rev Food Sci Nutr. 2019;59(sup1):S210-S243. doi:10.1080/10408398.2019.1565489. Epub 2019 Feb 11. PMID: 30740986. https://www.tandfonline.com/doi/full/10.1080/10408398.2019.1565489
9. Murlidhar Meghwal, Suparna Devu, Himani Singh, Tridib Kumar Goswami,Chapter 26 - Piperine and curcumin, Editor(s): Muhammad Mushtaq, Farooq Anwar, A Centum of Valuable Plant Bioactives, Academic Press, 2021, Pages 589-612, ISBN 9780128229231, https://doi.org/10.1016/B978-0-12-822923-1.00013-3 .
10. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. doi:10.1055/s-2006-957450. PMID: 9619120. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2006-957450

Maison Jacynthe disclaims all liability. All information contained on this page is not intended to replace justified allopathic treatment or to disregard the expertise of the medical profession. It is up to each individual to take charge of their own health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified health professional is obviously recommended.