A study was conducted on 85 women for 8 weeks on collagen, derived from fish source for skin protection. 1 The skin was evaluated on 3 criteria. It resulted in: an increase in facial skin moisture, an improvement in elasticity, also a significant reduction in the number of wrinkles and even the depth of wrinkles. 2 The authors of this study also found that it decreased the surface area of UV spots on the skin after 4 weeks of ingestion. 3
Also, improvements in skin properties were previously reported in another clinical study conducted with HC fish administered to 25 Japanese female subjects diagnosed with dry and rough skin. The results showed that moisture content increased significantly after 6 weeks; improvements such as elasticity thus reducing wrinkles and skin roughness. 4
Collagen and skin aging, linked to lifestyle habits!
Did you know that sugars affect skin aging? Glucose and fructose bind amino acids found in collagen and elastin, which support the dermis, producing advanced glycation end products (AGEs), or tissue aging products. This process is accelerated in all tissues of the body when sugar is high and is further stimulated by ultraviolet light in the skin. This is what this study tells us. 5
For example, the results of improved hydration and elasticity were also confirmed in the subgroup meta-analysis. Based on the results, ingesting hydrolyzed collagen for 90 days is effective in reducing skin aging, as it reduces wrinkles and improves skin elasticity and hydration. 6
Research has highlighted that both oral and topical collagen supplements help delay the aging process, with no difference between the two types of collagen. Evidence from the reviewed studies suggests that both collagen supplements improve skin moisture, elasticity, and hydration when administered orally. Additionally, collagen reduces wrinkles and skin roughness, and existing studies have found no side effects from its oral supplements. 7
After 12 weeks, participants supplemented (women between 45 and 60 years old) with marine collagen had a significant 35% reduction in wrinkle score (compared to baseline). Marine collagen supplementation was found to be safe and well tolerated. The results of this study support the use of fish-derived hydrolyzed collagen for the improvement of skin health in an aging population. 8
Prolonged exposure to the sun. 9
Smoking reduces collagen production and increases wrinkle formation. 10
Collagen and antioxidants
A study by Mendis et al. showed that the antioxidant power of HC is mainly due to the presence of hydrophobic amino acids in the peptide. These results indicated that peptides derived from marine fish proteins have greater properties. 11
In conclusion, according to these numerous studies, hydrolyzed collagen appears to be an effective bioactive ingredient for improving skin health and the effects of skin aging.
References:
1. Aguirre-Cruz G, León-López A, Cruz-Gómez V, Jiménez-Alvarado R, Aguirre-Álvarez G. Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation. Antioxidants (Basel). 2020 Feb 22;9(2):181. doi:10.3390/antiox9020181. PMID: 32098294; PMCID: PMC7070905.
2. Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial aging signs in a randomized double-blind placebo-controlled clinical study. J Sci Food Agriculture. 2016 Sep;96(12):4077-81. doi:10.1002/jsfa.7606. Epub 2016 Feb 10. PMID: 26840887.
3. Fumihito Sugihara, Naoki Inoue. Clinical effects of collagen hydrolysates ingestion on UV-induced pigmented sports of huma skin: A preliminary study. Health Sciences Vol. 28, No. 2 2012 Copy right 2012 by The Japan Society of Health Sciences
https://wellnex-collagen.com/wp-content/uploads/2018/06/NGI_5g-UVspot_HS28_12.pdf
4. Matsumoto H and al. Clinical effects of fish type I collagen hydrolyzate on skin properties. ITE Lett. On batteries, New technology & Medicine. 2006; Volume 7: p. 386-390
5. Danby FW. Nutrition and aging skin: sugars and glycation. Clin Dermatol. 2010 Jul-Aug;28(4):409-11. doi: 10.1016/j.clindermatol.2010.03.018. PMID: 20620757.
6. de Miranda RB, Weimer P, Rossi RC. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. 2021 Dec;60(12):1449-1461. doi: 10.1111/ijd.15518. Epub 2021 Mar 20. PMID: 33742704.
7. Atif H. Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics. Dermatol Pract Concept. 2022 Jan 1;12(1): e2022018. doi: 10.5826/dpc.1201a18. PMID: 35223163; PMCID: PMC8824545.
8. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021 Mar;20(3):825-834. doi: 10.1111/jocd.13676. Epub 2020 Sep 15. PMID: 32799362; PMCID: PMC8176521.
9. Bosch R, Philips N, Suárez-Pérez JA, Juarranz A, Devmurari A, Chalensouk-Khaosaat J, González S. Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals. Antioxidants (Basel). 2015 Mar 26;4(2):248-68. doi:10.3390/antiox4020248. PMID: 26783703; PMCID: PMC4665475.
10. Knuutinen A, Kokkonen N, Risteli J, Vähäkangas K, Kallioinen M, Salo T, Sorsa T, Oikarinen A. Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol. 2002 Apr;146(4):588-94. doi: 10.1046/j.1365-2133.2002.04694. x. PMID: 11966688.
11. Mendis E, Rajapakse N, Byun HG, Kim SK. Investigation of jumbo squid (Dosidicus gigas) skin gelatin peptides for their in vitro antioxidant effects. Life Sci. 2005 Sep 9;77(17):2166-78. doi: 10.1016/j.lfs.2005.03.016. PMID: 15916780.
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