Magnesium
What is magnesium? What is it used for?
Deficiency symptoms
Frequent : 75% of French people (SUVIMAX), > 40% of Canadians (Stats Can)
- Hyperexcitability
- CNS: anxiety, reduced resistance to stress, fatigue
- Muscular; muscle tension, spasm, fasciculations
- Cardiac: HBP, palpitations
- Lump in throat/feeling of tightness
- Insulin resistance
- Bone fragility
Difficult to diagnose
- blood/plasma vs intracellular
Where is it found?
https://www.passeportsante.net/fr/Solutions/PlantesSupplements/Fiche.aspx?doc=magnesium_ps
Effect of supplements
Cofactors:
- vitamin B6
- taurine
- Vitamin D
- calcium (sodium potassium)
Which Mg salt to choose?
Dosage?
Food or supplements?
Interaction :
- Medications to be taken on an empty stomach
- Medications for Parkinson's disease
- Muscle relaxants = increases the effect
- Gabapentin – reduces absorption
- Zinc supplement – competition
- Fiber, phytate and oxalates
has.https://lpi.oregonstate.edu/mic/minerals/magnesium
b. https://www.nutrimea.com/article/quel-magnesium-choisir/
References
Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. PMID: 26069819; PMCID: PMC4455825. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455825/
HTA
1. Rosanoff A, Plesset MR. Oral magnesium supplements decrease high blood pressure (SBP>155 mmHg) in hypertensive subjects on anti-hypertensive medications: a targeted meta-analysis. Magnes Res. 2013 Jul-Sep;26(3):93-9. doi: 10.1684/mrh.2013.0343. PMID: 24134861. https://www.jle.com/fr/revues/mrh/e-docs/oral_magnesium_supplements_decrease_high_blood_pressure_sbp_155mmhg_in_hypertensive_subjects_on_anti_hypertensive_medications_a_targeted_meta_analysis_298491/article.phtml
2. Zhang Hypertension. 2016 Aug;68(2):324-33. doi: 10.1161/HYPERTENSIONAHA.116.07664. PubMed PMID: 27402922. https://hyper.ahajournals.org/content/68/2/324.long
Symptoms of Magnesium Deficiency
Adapted from: Burford-Mason A. Orthomolecular Medicine ad Hearth Health: Unmasking the Magnesium Link to Multiple Risk Factors for Cardiovascular Disease. J Orthomolecular med 2013;28(1):9-16. In The Orthomolecular Treatment of Chronic Disease. Saul AW editor. Basic Health Publication USA 2014. P.376-381
- Do you have leg or foot cramps?
- Do your shoulders often feel tense at the end of the day?
- Do you have spasms/tension in your back?
- Have you ever had or do you have muscle fasciculations (muscle jumping)?
- Do you suffer from asthma or wheezing?
- Do you get out of breath after light exertion like climbing stairs?
- Do you sigh often?
- Do you have palpitations or an irregular heartbeat?
- Do you urinate often, especially at night?
- Are you constipated?
- Do you have type 2 diabetes or metabolic syndrome?
- Do you have high blood pressure?
Oxalate and phytate – inhibition of absorption. Therefore, the Mg from cereals will be very poorly absorbed: Inhibitory
- Effects can be exerted by high levels of partly fermentable fibers (ie, hemicellulose), non-fermentable fibers (ie, cellulose and lignin) and phytate and oxalate
- several dietary factors are known to enhance Mg2+ uptake, including proteins, MCT, and low- or indigestible carbohydrates such as resistant starch, oligosaccharides, inulin, mannitol and lactulose.
Schuchardt JP, Hahn A. Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update. Curr Nutr Food Sci. 2017 Nov;13(4):260-278. doi:10.2174/1573401313666170427162740. PMID: 29123461; PMCID: PMC5652077. https://www.ncbi.nlm.nih.gov/
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