Botanical formulas

Botanical formulas

STRENGTH : Used as an adaptogen to help increase energy and resistance to stress (e.g., in cases of stress-related mental and physical fatigue). (Astragalus, Siberian Ginseng, Licorice, Rhodiola, Shatavari, Guduchi)

IMMUNE : Helps relieve sore throats, reduce the duration and symptoms of upper respiratory infections (e.g., the common cold), maintain peripheral circulation, and maintain a healthy immune system. (Astragalus, Cayenne, Echinacea angustifolia, Echinacea purpurea, Vitamin B12)

Among their ingredients, we find:

Astragalus

Astragalus is a tonic and anti-aging herb. Its main components are polysaccharides, flavonoids, and saponins. Pharmacological research indicates that the component extracted from astragalus can increase telomerase activity and has effects: ^1,2,3,4,5,6

• Antioxidants
• Anti-inflammatories
• Immunoregulators
• Anticancer
• Hypolipidemic
• Antihyperglycemics
• Hepatoprotectors
• Expectorants
• Diuretics

1. Liu P, Zhao H, Luo Y. Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic. Aging Dis. 2017 Dec 1;8(6):868-886. doi: 10.14336/AD.2017.0816. PMID: 29344421; PMCID: PMC5758356. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758356/

2. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, et al. (2011). Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature, 469:102-106. https://pubmed.ncbi.nlm.nih.gov/21113150/

3. Ait-Ghezala G, Hassan S, Tweed M, Paris D, Crynen G, Zakirova Z, et al. (2016). Identification of telomerase-activating blends from naturally occurring compounds. Altern Ther Health Med, 22 Suppl 2:6-14. https://pubmed.ncbi.nlm.nih.gov/27433836/

4. Salvador L, Singaravelu G, Harley CB, Flom P, Suram A, Raffaele JM (2016). A natural product telomerase activator lengthens telomeres in humans: a randomized, double blind, and placebo-controlled study. Rejuvenation Res, 19:478-484. https://pubmed.ncbi.nlm.nih.gov/26950204/

5. Harley CB, Liu W, Flom PL, Raffaele JM (2013). A natural product telomerase activator as part of a health maintenance program: metabolic and cardiovascular response. Rejuvenation Res, 16:386-395. https://pubmed.ncbi.nlm.nih.gov/23808324/

6. Bernardes de Jesus B, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell. 2011 Aug;10(4):604-21. doi: 10.1111/j.1474-9726.2011.00700. x. Epub 2011 Apr 14. PMID: 21426483; PMCID: PMC3627294. https://pubmed.ncbi.nlm.nih.gov/21426483/

Cayenne

Cayenne pepper is renowned for its digestive and therapeutic properties. It stimulates digestion and improves peripheral circulation. Capsaicin, dihydrocapsaicin, and certain carotenoids are reported as the main active compounds with several pharmacological potentials, including:

• Anticancer
• Cardioprotective.

1. https://www.passeportsante.net/fr/Solutions/PlantesSupplements/Fiche.aspx?doc=cayenne_ps

2. Liu T, Wan Y, Meng Y, Zhou Q, Li B, Chen Y, Wang L. Capsaicin: A Novel Approach to the Treatment of Functional Dyspepsia. Mol Nutr Food Res. 2023 May;67(9):e2200793. doi: 10.1002/mnfr.202200793. Epub 2023 Mar 11. PMID: 36852548.

3. Mandal SK, Rath SK, Logesh R, Mishra SK, Devkota HP, Das N. Capsicum annuum L. and its bioactive constituents: A critical review of a traditional culinary spice in terms of its modern pharmacological potentials with toxicological issues. Phytother Res. 2023 Mar;37(3):965-1002. doi:10.1002/ptr.7660. Epub 2022 Oct 18. PMID: 36255140.

Echinacea angustifolia & Echinacea purpurea

According to in vitro studies, echinacea has beneficial effects on cold symptoms due to its anti-inflammatory function, particularly its ability to block the production of cytokines responsible for inflammation. ^1,2

The plant can act directly and immediately on the mucous membranes of the mouth and throat in the form of liquid extracts. This could make it more effective in cases of colds or respiratory infections. ³

In another study, it is mentioned that certain medicinal plants, notably Echinacea purpurea and Zingiber officinale, have a potential for adjuvant symptomatic treatment in respiratory conditions, such as: ⁴

• Chronic obstructive pulmonary disease
• Bronchitis
• Asthma
• The common cold
• Cough
• Whooping cough.

1. https://www.passeportsante.net/fr/Solutions/PlantesSupplements/Fiche.aspx?doc=echinacee_ps

2. Schwarz E, Metzler J, Diedrich JP, Freudenstein J, Bode C, Bode JC. Oral administration of freshly expressed juice of Echinacea purpurea herbs fail to stimulate the nonspecific immune response in healthy young men: results of a double-blind, placebo-controlled crossover study. J Immunother. 2002 Sep-Oct;25(5):413-20. doi:10.1097/00002371-200209000-00005. PMID: 12218779.

3. Barrett B et al. Echinacea for Treating the Common Cold. A Randomized Trial. Bruce Barrett, MD, PhD; Roger Brown, PhD; Dave Rakel, MD et al. Annals of Internal Medicine. Full text : www.annals.org

4. American Botanical Council Clarifies Echinacea Trial Published in Annals of Internal Medicine, December 21, 2010. cms.herbalgram.org

5. Firdaus A, Yunus MH, Izhar SK, Afaq U. Medicinal Plants in the Treatment of Respiratory Diseases and their Future Aspects. Recent Pat Biotechnol. 2024 Jan 24. doi: 10.2174/0118722083278561231212072408. Epub ahead of print. PMID: 38275072.

Siberian Ginseng

Siberian ginseng is a plant widely used in China, Japan, Korea and Russia for its beneficial effects on: ¹

• Improving memory
• Toning & nourishing the heart
• Tranquilizer

Triterpenoid saponins as well as phenylpropanoids, bioactive components of ginseng, have demonstrated promising properties such as: ²

• Antioxidant stress
• Anti-aging
• Platelet aggregation
• Antitumor effects
• Potential to improve glucose metabolism, cardiovascular and immune systems.

1. Zhou YX, Luo WJ, Zhou TT, Zhou Y, Li HL, Sun F, Ge YW, Piao XH. Precursor ions-guided comprehensive profiling of triterpenoid saponins from the Eleutherococcus senticosus stems and their neuroprotective effect evaluation. J Pharm Biomed Anal. 2024 Jan 20; 238:115849. doi: 10.1016/j.jpba.2023.115849. Epub 2023 Nov 7. PMID: 37979523.

2. Sun H, Feng J, Sun Y, Sun S, Li L, Zhu J, Zang H. Phytochemistry and Pharmacology of Eleutherococcus sessiliflorus (Rupr. & Maxim.) SY Hu: A Review. Molecules. 2023 Sep 11;28(18):6564. doi:10.3390/molecules28186564. PMID: 37764339; PMCID: PMC10536541.

Guduchi

Guduchi, the subject of much research, is used in several traditional medicines in the treatment of diseases. ¹ Its numerous constituents are terpenes, glycosides, alkaloids, steroids and flavonoids. A review highlights the pharmacological and promising potential of this rich herb in preventing and treating various diseases, for example, such as: ²

• Antioxidant
• Antihyperglycemic agent
• Antihyperlipidemic
• Hepatoprotective
• Cardiovascular protector
• Neuroprotective
• Osteoprotective
• Radioprotector
• Anti-anxiety
• Adaptogenic agent
• Analgesic
• Anti-inflammatory
• Antipyretic
• Thrombolytic
• Anti-diarrheal
• Antiulcer
• Antimicrobial
• Anticancer

1 . Gupta A, Gupta P, Bajpai G. Tinospora cordifolia (Giloy): An insight on the multifarious pharmacological paradigms of a most promising medicinal ayurvedic herb. Heliyon. 2024 Feb 15;10(4): e26125. doi: 10.1016/j.heliyon. 2024.e26125. PMID: 38390130; PMCID: PMC10882059.

2. Dhama K, Sachan S, Khandia R, Munjal A, Iqbal HMN, Latheef SK, Karthik K, Samad HA, Tiwari R, Dadar M. Medicinal and Beneficial Health Applications of Tinospora cordifolia (Guduchi): A Miraculous Herb Countering Various Diseases/Disorders and its Immunomodulatory Effects. Recent Pat Endocr Metab Immune Drug Discov. 2017;10(2):96-111. doi:10.2174/1872214811666170301105101. PMID: 28260522.

Licorice

An adaptogenic plant, licorice has expectorant properties to dissolve and facilitate the evacuation of mucus in cases of catarrh and for upper respiratory tract diseases. ¹

A review also summarizes the results of studies related to liver, gastrointestinal, oral, skin and metabolic disorders confirming the properties of licorice, such as: ²

• Anti-inflammatory
• Antioxidant
• Immunomodulatory

1. https://www.pharmacompass.com/pAssets/pdf/pubchem/glycyrrhiza-glabra-l.pdf

2. Panossian A, Brendler T. The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections. Pharmaceuticals (Basel). 2020 Sep 8;13(9):236. doi:10.3390/ph13090236. PMID: 32911682; PMCID: PMC7558817.

Rhodolia

Rhodiola is a popular plant whose roots and rhizomes have been used since ancient times to relieve stress, fatigue, and mental and physical ailments. Its properties include:

• Antioxidant
• Immunomodulatory
• Anti-aging
• Anti-fatigue
• Improves mental and cognitive functions
• Protects the central nervous system and heart in case of stress
• Lipid-lowering agent
• Analgesic
• Antiradiation
• Antitumor
• Antidepressant
• Anti-inflammatory
• Improves intestinal digestive enzyme activities, inflammatory response and expression of intestinal barrier-related genes, as well as microbiota dysbiosis

1. Bernatoniene J, Jakstas V, Kopustinskiene DM. Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases. Int J Mol Sci. 2023 Jul 31;24(15):12293. doi:10.3390/ijms241512293. PMID: 37569669; PMCID: PMC10418374.

2. Mueller JK, Muller WE. Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on Ginkgo biloba and Rhodiola rosea. J Neural Transm (Vienna). 2024 Mar;131(3):203-212. doi:10.1007/s00702-024-02749-3. Epub 2024 Feb 12. PMID: 38347175; PMCID: PMC10874325.

3. Zheng L, Wang Z, Zhang B, Yan L, Wang P, Zhao C, Wang J, Wang Y, Lin H, Qiu L, Zhou C. Rhodiola rosea L. improved intestinal digestive enzyme activities, inflammatory response, barrier and microbiota dysbiosis in Lateolabrax maculatus juveniles fed with high-carbohydrate diets. Fish Shellfish Immunol. 2024 Mar; 146:109362. doi: 10.1016/j.fsi.2024.109362. Epub 2024 Jan 11. PMID: 38218423.

Shatavari

Shatavari ( Asparagus racemosus ) is one of those well-documented nutraceuticals in the ancient Greek, Chinese, and Ayurvedic system of medicine, known for its various medicinal benefits. It is used, among other things, in Ayurveda as a nervine tonic. The whole plant possesses therapeutic activities, such as: ^1,2

• Pleiotropic
• Antioxidant
• Anti-inflammatory
• Immunomodulatory
• Neuroprotective
• Nootropic
• Antidepressant.

1. Majumdar S, Gupta S, Prajapati SK, Krishnamurthy S. Neuro-nutraceutical potential of Asparagus racemosus: A review. Neurochem Int. 2021 May;145:105013. doi: 10.1016/j.neuint.2021.105013. Epub 2021 Mar 6. PMID: 33689806.

2. Singh N, Garg M, Prajapati P, Singh PK, Chopra R, Kumari A, Mittal A. Adaptogenic property of Asparagus racemosus: Future trends and prospects. Heliyon. 2023 Apr 1;9(4): e14932. doi: 10.1016/j.heliyon. 2023.e14932. PMID: 37095959; PMCID: PMC10121633.

Vitamin B12

Vitamin B12 can help balance immune responses to better fight viral infections. ¹

Another study also mentions that vitamin B12 acts as an immunomodulator of cellular immunity. ²

1. Batista KS, Cintra VM, Lucena PAF, Manhães-de-Castro R, Toscano AE, Costa LP, Queiroz MEBS, de Andrade SM, Guzman-Quevedo O, Aquino JS. The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection. Nutr Rev. 2022 Feb 10;80(3):561-578. doi: 10.1093/nutrit/nuab092. PMID: 34791425; PMCID: PMC8689946.

2. Tamura J, Kubota K, Murakami H, Sawamura M, Matsushima T, Tamura T, Saitoh T, Kurabayshi H, Naruse T. Immunomodulation by vitamin B12: increase of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol. 1999 Apr;116(1):28-32. doi: 10.1046/j.1365-2249.1999.00870. x. PMID: 10209501; PMCID: PMC1905232.

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Maison Jacynthe disclaims all liability. All information contained in this article or letter is not intended to replace justified allopathic treatment or to disregard the expertise of the medical profession. It is up to each individual to take charge of their own health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified healthcare professional is strongly recommended.