Probiotics for children, much more than a probiotic!

Probiotic that contributes to a healthy natural intestinal flora.

The ingredients in these probiotics have been shown to have beneficial effects on health. Here's what the literature describes regarding the indications for the strains found in them, including:

Lactobacillus Acidophilus LAC 361 (1.0 x 10 ⁹ CFU)

Bifidobacterium Longum BB536 (0.7 x 10 ⁹ CFU)

Bifidobacterium Breve M16V (0.5 x 10 ⁹ CFU)

Bifidobacterium Infantis M63 (0.5 x 10 ⁹ CFU)

Arabinogalactan (600 mg)

Documentation specific to strains of Probiotics for children

Reduction in the number of infections (20/75 vs 33/87 control) and the duration of hospitalizations (average 89.6 days vs 102.3 days control) by the administration of bifidobacteria (M16) in premature infants.

1. Sato Y, Shinohara K, Shiga S, et al. Effect of administration of bifidobacteria in premature infants. Acta Neonatalogia Japonica 2003;39(2): 247

Prevention of nosocomial MRSA infections in premature babies. (Before: MRSA carriers 30.5% & declared infections (NTED) 9.5%; After administration of Bifido M16: Carriers 12.3% and NTED 2.2%)

2. Yamada T, Ogino S, Uchino N, et al. Infection control against methecillin-resistant Staphylococcus aureus (MRSA) in neonatal intensive care unit. (Does administration of bifidobacterium prevent MRSA infection?) Acta Neonatalogia Japonica 2002;38:294.

Reduction of allergy and atopy (eczema) in newborns. Effect of reducing allergic symptoms, especially cutaneous (P=0.0176 for cutaneous symptoms and P=0.0117 for the total allergy score).

3. Hattori K, Yamamoto A, Sasai M, et al. Effects of administration of bifidobacteria (M16) on fecal microflora and clinical symptoms in infants with atopic dermatitis. 2003 Jan;52(1): 20-30.

Reduction of intestinal inflammatory markers in children with cystic fibrosis or inflammatory bowel disease (IBD) (BB536).

4. Bruzzese E, Gaudiello G, Polito G et al. Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration. Food Pharmacol Ther 2004; 20:813-819.

Documented effects of probiotics in children

Reduction of the duration of diarrhea and acceleration of the elimination of rotavirus in infectious gastroenteritis (daycare centers).

5. Saavedra JM, Bauman NA, Oung I. et al. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhea and shedding of rotavirus. Lancet 1994; 344: 1046-1049

Reduction of antibiotic-associated diarrhea

6. D'Souza AL, Rajkumar C, Cooke J and Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhea: meta-analysis. BMJ 2002;324(7350): 1361-1369.
7. Cremonini F. Di Caro S. Nista EC et all. Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhea. Food Pharmacol Ther. 2002; 16:1461-1467.
8. Charrois TL, Sandhu G, Vohra S. Probiotics. Pediatr Rev. 2006 Apr;27(4): 137-9.

Prevention of allergies, eczema and atopy

9. Furrie E. Probiotics and allergy Proc Nutr Soc (2005), 64, 465–469

• Bongaerts GPA, Severijnen RSVM. Preventive and curative effects of probiotics in atopic patients. Medical Hypotheses (2005) 64, 1089–1092
• Bengmark S, Martindale R. Prebiotics and synbiotics in clinical medicine. Nutr Clin Pract. 2005 Apr; 20(2): 244-61.

Food safety . No toxicity, no interaction transmission, no contamination in ambulatory users.

• Salminen S, von Wright. Current probiotics-safety assured? Microb Ecol Health Dis 1998; 10:68-77.

Documented effects of arabinogalactan

Improves intestinal flora (prebiotic effect) by increasing the concentration of beneficial Bifidobacteria and Lactobacilli.

Improves several functional aspects of the immune system : Activates macrophage phagocytosis and stimulates the effectiveness of the immune system's natural killer (NK) cells. It therefore has an immunostimulating effect in addition to its prebiotic effect.

Measurable reduction in the level of toxins in the intestine (fecal ammonia) therefore improvement of intestinal ecology.

Food safety . Recognized as dietary fiber by the US FDA (up to 30g per day without problems or adverse effects). Its only possible side effect is a slight bloating in 3% of high-dose users.

• Kelly GS. Larch Arabinogalactan: Clinical Relevance of a Novel Immune- Enhancing Polysaccharide. Altern Med Rev 1999; 4(2): 96-103
• Nantz, MP, Painter, AR, Parker, ERB, McGill, C. and Percival, SS Evaluation of Arabinogalactan's Effect on Human Immunity. Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611
• Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr. 2001 Aug;20(4):279-85.
• https://www.arabinogalactan.com/larex/welcome/raw_materials/immunenhancer.-ParSys-0008-DownloadFile.tmp/ImmunEnhancer.pdf

Various additional studies

• Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants.

Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis in very low birth weight infants.

DOI: 10.1542/peds.2004-1463 Pediatrics 2005;115;1-4 Tsu-Fuh Yeh and William Oh Hung-Chih Lin, Bai-Horng Su, An-Chyi Chen, Tsung-Wen Lin, Chang-Hai Tsai, V - https://www.pediatrics.org/cgi/content/full/115/1/

• Effects of oral administration of Bifidocbacterium longum on the development of intestinal microflora in extremely premature infants (comparison with Bifidobacterium breve ).

Effects of oral administration of Bifidocaterium longum on the development of the intestinal microflora in extremely preterm infants (comparison with Bifidocaterium breve) - Acts of Acta Neonatoligica Japonica 30, 257-263 (1994)

• Effects of bifidobacteria administration on fecal microflora and clinical symptoms in infants with atopic dermatitis.

Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis. - Bifidobacterium breve M-16V 1: Arerugi. 2003 Jan;52 (1): 20-30

• An increased poliovirus-specific intestinal antibody response coincides with the promotion of Bifidobacterium longum-infantis and Bifidobacterium breve in infants: a randomized, double-blind, placebo-controlled trial.

Increased Poliovirus-Specific Intestinal Antibody Response Coincidences with Promotion of Bifidobacterium longum-infantis and Bifidobacterium breve in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial - International Pediatric Research Foundation, Inc - 2004

• Effects of bifidobacteria administration in premature infants

Effects of administration of bifidobacteria in premature infants - Acts Neonatologics Japonica, 39 (2): 247, 2003

• Methicillin-resistant Staphylococcus aureus (MRSA) infection control in the neonatal intensive care unit (Does administration of Bifidobacterium prevent MRSA infection?)

Infection control against methicillin resistant Staphylococcus aureus (MRSA) in neonatal intensive care unit (Does administration of Bifidobacterium prevent MRSA infection?) – Acts Neonatologics Japonica, 38, 294, 2002