Menopause Formula - MJ Tonic - To help reduce menopause symptoms
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Helps maintain cognitive functions and/or reduce mental fatigue (in case of mental stress).
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Helps to increase physical abilities/physical performance (in case of physical stress).
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Helps to increase energy and stress resistance (in cases of mental or physical fatigue related to stress).
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Helps relieve symptoms associated with menopause such as hot flashes, night sweats, paresthesia (tingling, skin burning sensation), insomnia, nervousness, dizziness, fatigue, rheumatic pain, and vaginal dryness.
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Helps relieve symptoms associated with menopause such as hot flashes, night sweats, paresthesia (tingling, burning sensation of the skin), insomnia, nervousness, dizziness, fatigue, rheumatic pain, and vaginal dryness.
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Provides antioxidants.
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Helps reduce hot flashes associated with menopause.
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Salvia officinalis, helps reduce hyperhidrosis/excessive sweating.
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Provides antioxidants.
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Helps reduce hot flashes associated with menopause.
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Salvia officinalis, helps reduce hyperhidrosis/excessive sweating (antihydrotic).
Its ingredients:
Angelica gigas (Giant angelica root), Cynanchum wilfordii (Wilford's cynanchum root), and Phlomis umbrosa (Sok-dan root).
The blend of these three plants, Angelica gigas (Giant angelica root), Cynanchum wilfordii (Wilford's cynanchum root), and Phlomis umbrosa (Sok-dan root), is known as: EstroG-100®. Here are various studies that demonstrate what this blend can offer, in terms of actions and benefits, during the pre-, peri-, and post-menopausal periods:
In a 12-week clinical trial involving 64 women, with 33 receiving EstroG-100® and 31 receiving a placebo, treatment with EstroG-100® showed a statistically significant improvement in the group taking EstroG-100®: on various menopausal symptoms such as hot flashes, night sweats, paresthesia, insomnia, nervousness, melancholy, dizziness, fatigue, rheumatic pain, and vaginal dryness. No adverse effects were reported with EstroG-100®. There were no significant changes in body weight, BMI, serum E2 levels, serum FSH levels, or liver enzymes. 1
In another study, researchers examined the safety of the plant mixture to determine its estrogenic activity. It was found that this mixture had no estrogenic activity and did not stimulate promoters containing estrogen response elements in certain cells. 2
A scientific group, after evaluating additional information on this blend, considers that the conclusion of the scientific opinion on the safety of EstroG‐100® does not need to be revised. This group reconfirms that this blend, as a novel food, is safe for use in dietary supplements at the maximum intake level of 175 mg/day for postmenopausal women. 3
Panax ginseng (Ginseng)
Red ginseng (Panax ginseng) has been widely used to treat various diseases in East Asian countries. Previous studies have shown the antioxidant and antidiabetic effects. A study aimed to investigate the effects of red ginseng on oxidative stress and insulin resistance in postmenopausal women.
A double-blind, randomized placebo-controlled trial in 82 postmenopausal women aged 45 to 60. The participants were randomized to receive 3 g of red ginseng per day or a placebo for 12 weeks. The activity of antioxidant enzymes (and oxidative stress markers were evaluated, and the homeostatic model assessment of insulin resistance was calculated at the beginning and end of the trial). A total of 71 postmenopausal women completed the study. The activity of serum superoxide dismutase significantly increased after red ginseng supplementation over a period of 12 weeks (P <0.001), and these changes were statistically significant compared to the placebo group (P = 0.004). Among other things, red ginseng supplementation showed no effect on fasting blood glucose, fasting insulin, and insulin resistance. It was concluded that red ginseng can therefore reduce oxidative stress by increasing antioxidant enzyme activity in postmenopausal women. 4
Postmenopausal women are vulnerable to aging and oxidative stress due to the reduction of estrogen.
Previous studies have shown that Korean red ginseng has beneficial effects on aging and antioxidant capacity. Here, we evaluated the effects of red ginseng on biological aging and antioxidant capacity in postmenopausal women. A double-blind, placebo-controlled clinical trial was conducted with participants who were randomly assigned to receive either red ginseng or a placebo, and the following parameters were measured: the number of mitochondrial DNA copies as an indicator of biological aging and total antioxidant status as a marker of antioxidant capacity. The clinical symptoms of fatigue were assessed before and after the administration of red ginseng. There were 63 participants, of whom 33 received ginseng and 30 received a placebo. The results showed that the administration of 2 g/day of red ginseng for 8 weeks increased the number of mtDNA copies, increased antioxidant activity, and reduced fatigue symptoms more than the placebo. 5
In recent years, the various effects of red ginseng, including the improvement of immunity, relief of fatigue, enhancement of memory, improvement of blood circulation, antioxidation, alleviation of menopausal symptoms, and anticancer effects, have been reported in clinical and fundamental research; red ginseng would hold an important place as a functional food for health, as indicated in this monograph providing accurate information on red ginseng. These cited claims have been approved by the Korean Food and Drug Administration. 6
For example, it is also reported that the consumption of red ginseng:
- Prolonged the total sleep duration and either increased sleep efficiency or prolonged sleep of stages 2 and 3.
- A study on patients with dry mouth reports that red ginseng improved dry mouth in the secondary analysis of postmenopausal women among the participants.
- It is also reported that the consumption of red ginseng for 24 weeks would have increased both the density and thickness of hair in patients with male and female pattern hair loss.
A study was conducted to determine the effect of ginseng on sexual function, quality of life, and menopausal symptoms in postmenopausal women with sexual dysfunction. 7
This randomized controlled trial was conducted on 62 women who were randomly assigned to intervention/control groups using block randomization. The intervention group received 500 mg of Panax Ginseng and the control group received a placebo twice a day for four weeks. It is reported that there were no statistically significant differences between the two groups in terms of demographic characteristics and baseline scores of sexual functions, quality of life, and menopausal symptoms. However, after the intervention, the mean total score of the Female Sexual Function Index was significantly higher in the intervention group compared to the control group. (placebo). The average total score of quality of life and menopausal symptoms was significantly lower in the treatment group than in the control group. (placebo). It was concluded that ginseng has significant effects on improving sexual function and quality of life and on alleviating menopausal symptoms, and that it can be an appropriate alternative to conventional therapies to promote the health of menopausal women.
Salvia officinalis (Common sage)
Due to the side effects of hormone therapy, medicinal plants and complementary medicines still hold great interest for the treatment and management of menopause symptoms and complications, such as hot flashes, one of the most common problems during menopause.
A review article was conducted by examining clinical trial studies between 1994 and 2016. The keywords, which include menopause, climacteric, hot flashes, herbs, and phytoestrogens, were used to search for herbal medicines used in clinical trials for the treatment of menopausal symptoms using databases such as PubMed, Medline, Scopus, Google Scholar, SID, and Magiran. The results of the study showed that several medicinal plants, including sage (Salvia officinalis), were effective in treating acute menopause syndrome through various mechanisms. 8
Regarding hot flashes but also, night sweats, sleep disturbances, etc...
In a double-blind, randomized controlled clinical trial conducted at the Namazi Hospital Bone Density Center in Shiraz, 66 menopausal women complaining of menopausal symptoms were divided into two intervention and control groups, respectively. The intervention group received 100 mg tablets of Salvia officinalis extract, at a rate of three tablets per day for 3 months, while the control group received placebo tablets. Questionnaires were completed at the beginning and end of the study. The checklists for hot flashes and night sweats were completed one week before the intervention and at weeks 2, 4, 6, 8, 10, and 12 during the intervention. Finally, the data were analyzed using paired questionnaires and a significant threshold of 5% was considered. According to this test, the average score for hot flashes, palpitations, sleep disturbances, muscle and joint pain, depression, nervousness, anxiety, and sexual desire and satisfaction significantly decreased by 1.6, 0.4, 1.6, 2.1, 1.4, 1.2, 1.6, and 0.8 units, respectively, in the intervention group compared to the placebo control group (P < 0.001). Therefore, the average score of one of the questionnaires significantly decreased by 3.8 units in the intervention group after the intervention (9.4 ± 3.7 vs 5.6 ± 1.9 (P < 0.05). These results showed that the extract of Salvia officinalis effectively improved menopausal symptoms such as hot flashes, night sweats, heart palpitations, muscle and joint pain, depression, anxiety, sleep disturbances, and sexual desire.9
References :
1. Chang A, Kwak BY, Yi K, Kim JS. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. 2012 Apr;26(4):510-6. doi: 10.1002/ptr.3597. Epub 2011 Sep 2. PMID: 21887807. https://pubmed.ncbi.nlm.nih.gov/21887807/
2. Kim SJ, Jin SW, Lee GH, Kim YA, Jeong HG. Evaluation of Estrogenic Activity of Extract from the Herbal Mixture Cynanchum wilfordii Hemsley, Phlomis umbrosa Turczaninow, and Angelica gigas Nakai. Toxicol Res. 2017 Jan;33(1):71-77. doi: 10.5487/TR.2017.33.1.071. Epub 2017 Jan 15. PMID: 28133516; PMCID: PMC5266372. https://pubmed.ncbi.nlm.nih.gov/28133516/
3. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D, Bresson JL, Burlingame B, Dean T, Fairweather-Tait S, Heinonen M, Hirsch-Ernst KI, Mangelsdorf I, McArdle HJ, Naska A, Neuhäuser-Berthold M, Nowicka G, Pentieva K, Sanz Y, Siani A, Sjödin A, Stern M, Tomé D, Vinceti M, Willatts P, Engel KH, Marchelli R, Pöting A, Poulsen M, Schlatter JR, Turla E, van Loveren H. Statement on the safety of EstroG-100™ as a novel food pursuant to Regulation (EC) No 258/97. EFSA J. 2017 May 8;15(5):e04778. doi: 10.2903/j.efsa.2017.4778. PMID: 32625484; PMCID: PMC7010173. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010173/#:~:text=In%20that%20scientific%20opinion%2C%20the%20Panel%20concluded%20that%20EstroG%E2%80%90100,(514%20mg%2Fday)
4. Seo SK, Hong Y, Yun BH, Chon SJ, Jung YS, Park JH, Cho S, Choi YS, Lee BS. Antioxidative effects of Korean red ginseng in postmenopausal women: a double-blind randomized controlled trial. J Ethnopharmacol. 2014 Jul 3;154(3):753-7. doi: 10.1016/j.jep.2014.04.051. Epub 2014 May 9. PMID: 24814037. https://pubmed.ncbi.nlm.nih.gov/24814037/
5. Chung, T.-H.; Kim, J.-H.; Seol, S.-Y.; Kim, Y.-J.; Lee, Y.-J. The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study. Nutrients 2021, 13, 3090. https://doi.org/10.3390/nu13093090
6. So SH, Lee JW, Kim YS, Hyun SH, Han CK. Red ginseng monograph. J Ginseng Res. 2018 Oct;42(4):549-561. doi: 10.1016/j.jgr.2018.05.002. Epub 2018 May 26. PMID: 30337816; PMCID: PMC6190493. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190493/
7. Ghorbani Z, Mirghafourvand M, Charandabi SM, Javadzadeh Y. The effect of ginseng on sexual dysfunction in menopausal women: A double-blind, randomized, controlled trial. Complement Ther Med. 2019 Aug; 45:57-64. doi: 10.1016/j.ctim.2019.05.015. Epub 2019 May 22. PMID: 31331583. https://pubmed.ncbi.nlm.nih.gov/31331583/
8. Kargozar R, Azizi H, Salari R. A review of effective herbal medicines in controlling menopausal symptoms. Electron Physician. 2017 Nov 25;9(11):5826-5833. doi: 10.19082/5826. PMID: 29403626; PMCID: PMC5783135. https://pubmed.ncbi.nlm.nih.gov/29403626/
9. Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, Sasani MR, Emamghoreishi M, Akbarzadeh M. The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women. J Family Med Prim Care. 2020 Feb 28;9(2):1086-1092. doi: 10.4103/jfmpc.jfmpc_913_19. PMID: 32318472; PMCID: PMC7114003. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114003/
Warning: Maison Jacynthe disclaims all responsibilities. All the information contained on this page does not seek to substitute a justified allopathic treatment nor to dismiss the expertise of the medical profession. It is up to each individual to take charge of their health, to inform themselves, and to make the necessary changes to improve their condition. Therapeutic supervision by a qualified healthcare professional is obviously recommended.
